摘要
目的研究慢性病毒性肝病与胃十二指肠粘膜病变之间的关系以及慢性病毒性肝病时胃十二指肠粘膜病变的发病机制．方法内镜检查患者１２７例，检查前临床诊断为慢性病毒性肝病组４６例（其中男３９例，女７例，年龄４０３岁±１２９岁）和胃肠病组８１例（其中男５３例，女２８例，年龄３９８岁±１３４岁），进行内镜检查结果比较．结果慢性病毒性肝病组和胃肠病组的ＰＵ，ＣＳＧ发生率分别为３９１％，１００％和４３２％，９８８％，无统计学差异（Ｐ＞００５）．慢性病毒性肝病组的ＧＥＶ，ＤＩ，ＥＩ和ＢＲＧ发生率分别为４０３％，６９６％，３０４％和６０９％，胃肠病组为７４％，２８４％，６２％和１２４％，二者间有显著性差异（Ｐ＜００１）．ＧＥＶ检出率在慢性病毒性肝病组中，活动型肝硬变、慢性肝炎重度与慢性肝炎轻中度比较差异显著（分别为６６７％，５３１％和００％，Ｐ＜００１）．结论慢性病毒性肝病时胃十二指肠粘膜病变发生率较高，肝功能减退及肝炎病毒感染等在胃十二指肠粘膜病变的发病中起重要作用．
AIM To study the relationship between chronic viral hepatopathy (CVH) and gastroduodenal mucosal lesions (GDML) and the mechanism of GDML in CVH patients. METHODS The patients ( n =127) were divided into 2 groups clinically before gastroscopy, CVH group ( n= 46, male 39, female 7, 40 3±12 9 years) and gastroenteropathy (GEP) group ( n =81, male 53, female 28, 39 8±13 4 years) and observed through endoscopy. Then various GDMLs in CVH patients were compared with GEP (GDML without CVH) patients. RESULTS No differences were demonstrated statistically in the occurrence rates of PU and CSG between CVH and GEP groups (39 1% and 100 0% vs 43 2% and 98 8%, P >0 05). The positivity rates of GEV, DI, EI and BRG were 40 3%, 69 6%, 30 4% and 60 9% in CVH group, which were significantly higher as compared with GEP group (7 4%, 28 4%, 6 2% and 12 4%, P <0 01). The positivity rate of GEV was obviously higher in patients with active liver cirrhosis (ALC) and chronic severe hepatitis (CSH) than those with other chronic hepatitis (CH) (66 7% and 53 0% vs 0 0%, P <0 01). CONCLUSION GDMLs are common in CVH patients. Liver dysfunction and HV infection play important roles in the development of GDML.
关键词
病毒性肝炎
胃疾病
十二指肠疾病
病理
hepatitis, viral, human/complications
gastrointestinal diseases/etiology
chronic disease
