摘要
作者通过对27名健康自愿受试者用20％十二烷基硫酸钠（SDS）水溶液进行不同封闭时间的HillTop皮肤斑站试验和FINN皮肤斑贴试验，并分别在15min、24h．48h、72h和7d进行观察。结果4hHillTop试验法阳性反应率为77．78％（21／27），FINN试验法阳性反应率为37．04％（10／27）；3hHillTop试验法为44.44％（12／27），FINN试验法为7.41％。HillTop试验法阳性反应率明显高于FINN试验法（P＜0．05）．这两种方法在不同封闭时间的阳性反应情况呈直线相关（r＝0．997）。从普通皮肤反应、皮肤结痴反应和综合皮肤反应分别进行观察，普通皮肤反应以24和48h，皮肤结痴反应以48和72h和综合皮肤反应以24、48和72h最明显。作者认为4hHillTop试验法是化学物质（包括化妆品）皮肤刺激性安全性评价和刺激性接触性皮炎诊断的首选方法之一。
27 hca1th volunteers were tested by different-time HILL T0P meethod and FINN method with 20%sodium dodecyl su1phate solution. The patches were removed at 15 min, 24h,48h, 72h and 7 days. The positive rate of4-hour HILL T0P method was 77. 78% (21/27), that of 4-hour FINN method was 37. 04K (10/27), that of 3-hourHILL T0P method was 44. 44% (12/27),and that of 3-hour FINN method was 7. 41 K (2/27)- The positive rates ofHILL T0P mehtod was 7- 41N (2/27). Tbe positive rates of HILL T0P method were bigbter than that of FINNmeethod signficantly (P<0- O5)- The best obvious time of Common Dermal Reaction were at 24h and 48h after thepatdh removal,that of Scabing Reaction were at 48h and 72h,and that of Summarized Dermal Reaction were at 24h,48h and 72h- The autors suggested that 4-hour HILL TOP method might be one of the main test method for itritantcontact dermatitis diagnosis and cosmetics safety eva1uation.
出处
《日用化学工业》
CAS
CSCD
北大核心
1997年第3期45-47,共3页
China Surfactant Detergent & Cosmetics
