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副肿瘤综合征的最新进展 被引量：9

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摘要 副肿瘤综合征是癌肿对神经系统的远隔效应,不是其直接转移浸润所致;此病发病率低;免疫系统对癌细胞及神经元共同抗原作出的免疫应答导致神经系统损害是本病的主要发病机制,细胞免疫可能对累及中枢神经系统的副肿瘤综合征的发病起了重要作用;临床特点多样化;根据新的诊断标准,确诊最主要是典型的临床表现;治疗尚无特效疗法,多采用肿瘤治疗和免疫调节疗法,疗效及预后不佳。
作者 刘馨 杨丽
机构地区 天津医科大学总医院神经内科
出处 《国外医学（老年医学分册）》 2008年第2期86-90,共5页 Foreign Medical Sciences(Geriatrics)
关键词 副肿瘤综合征 发病机制 临床特点 诊断 治疗
分类号 R730.4 [医药卫生—肿瘤]
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参考文献20

  • 1Tomimitsu H, Arimura K, Nagado T et al. Mechanism of aetion of voltage - gated K^+ channel antibodies in acquired neuromyotonia. Ann Neurol, 2004 ; 56 (3) : 440 - 444.
  • 2Fukuda T, Motomura M, Nakao YK et al. Reduction of P/ Q-type calcium channels in the postmortem cerebellum of paraneoplastic cerebellar degeneration with Lambert - Eaton myastbenic syndrome: Ann Neurol, 2003; 53 ( 1 ) : 21 - 28.
  • 3Pozo - Rosieh P, Clover L, Saiz A et cd. Voltage - gated potassium channel antibodies in limbie encephalitis. Ann Neurol, 2003; 54 (4): 530-533.
  • 4Albert ML, Austin LM, Darnell RB. Detection and treatment of activated T cells in the cerebroepinal fluid of patients with paraneoplastic cerebellar degeneration. Ann Neurol, 2000; 47 (1): 9-17.
  • 5Tanaka K, Ding X, Tanaka M. Effects of anfineuronal antibodies from patients with paraneoplastie neurological syndrome on primary cultured neurons. J Neurol Sei, 2004; 217:25-30.
  • 6Plonquet A, Garcia -Pons F, Fernandez E et al. Peptides derived from the oneoneural HuD protein can elicit eytotoxie responses in HHD mouse and human. J Neuroimmunol, 2003; 142 (1-2): 93-100.
  • 7Darnell RB. Paraneoplastic neurologic disorders: windows into neuronal function and tumor immunity. Arch Neurol, 2004; 61 (1): 30-32.
  • 8Yu Z, Kryzer TJ, Grlesmann GE et al. CRMP - 5 neuronal autoantibody : marker of lung cancer and thymoma - related autoimmunity. Ann Neurol, 2001 ; 49 (2) : 146 - 154.
  • 9Pelkofer H, Schubart AS, Hoftberger R et al. Modelling paraneoplastie CNS disease: T - cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalitis in the rat. Brain, 2004; 127:1822 -1830.
  • 10Rees JH. Paraneoplastic syndromes: when to suspect, how to confirm, and how to manage. J Neurol Neurosurg Psychiatry, 2004; 75 (suppl 1 -2) : ii43 -ii50.

同被引文献49

  • 1王莉莉,任艳.副肿瘤综合征[J].国外医学（神经病学．神经外科学分册）,2004,31(6):532-535. 被引量：15
  • 2何祥英,吴远怡.神经系统副肿瘤综合征10例分析[J].中国误诊学杂志,2006,6(23):4690-4691. 被引量：2
  • 3Dropcho EJ. Remote neurologic manifeslations of cancer[J]. Neurologic Clinics, 2002,20 (1) :85-122.
  • 4Graus F,Delatt re J Y,Antoine JC,et al.Recommended diagnostic criteria for paraneoplastic neurological syndromes.J Neurol Neurosurg Psychiat ry,2004,75(8):1135.
  • 5Grant,Riobin1What the general neurologist needs to know about the paraneop lastic Syndromes.Practical Neurology,2002,2(6):318-324.
  • 6Kaiser R. Paraneoplastic neurologic syndromes:diagnostic and pathoge- netic significance of autoantibodies [ J]. Nervenarzt, 1999,70 (8) :688- 701.
  • 7Flecher CF, Okano H J, Gilbert DJ. Mouse chromosomal locations of nine genes encoding homo]ogs of human paraneoplastic neurologic disorder antigens [ J ]. Genomics, 1997,45 ( 2 ) : 313.
  • 8Peterson K, Rosenblum MK, Kotanides H, et al. Paraneoplastic cerebellar degeneration:A clinical analysis of 55 anti-Yo antibody-positive patients [ J ]. Neurology, 1992,42 ( 10 ) : 1931.
  • 9Ogawa M. Nishie M, Kurahashi K. Anti-Hu associated paraneoplastic sensory neuopathy with upper motor neurone involvement[ J]. J Neurol Neurosurg Psychial,2004 ,75 (7) : 1051-1053.
  • 10Bash S, Alavi A. Role of FDG-PET in the clinical management of para- neoplastic neurological syndrome:detection of the underlying malignan- cy and the brain PET-MRI correlates[ J]. Mol Imaging Biol,2008,10: 131-137.

引证文献9

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国外医学（老年医学分册）
2008年 第2期

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