摘要
目的提高对甲状腺嗜酸细胞肿瘤的临床病理特点、诊断与鉴别诊断的认识,减少误诊。方法对2例甲状腺嗜酸细胞性肿瘤进行临床病理分析及免疫组织化学染色观察,并复习相关文献。结果1例嗜酸细胞性腺瘤,1例嗜酸细胞性滤泡癌,2例均为女性,年龄分别为55岁、62岁,手术后无复发。肿瘤较大,直径约5cm和8cm,有包膜,实性。组织学,瘤细胞大小形态较一致,核圆形或卵圆形,核异形不明显,核分裂罕见,丰富的嗜酸性胞质为其特征。两者的鉴别主要点是有无包膜和/或血管浸润。良性和恶性嗜酸细胞性肿瘤均表达TG、vimentin、S-100,CEA。结论甲状腺嗜酸细胞性肿瘤的临床病理和免疫组织化学特点与甲状腺其他相对应类型的肿瘤相似。
Objective To improve one＇s knowledge of the clinicopathological characteristics,the diagnosis and differential diagnosis of Hurthle cell tumors （HCT） of the thyroid, and to decrease the rate of misdiagnosis. Methods Two cases of hurthle cell turmors was studied with clinicopathologic data and immunohistechemical techniques, and also with review of the literature. Results There was one case of the Turthle cell adenomas, one Hurthle cell follicular carcinomas. Two patients were young adult females, 35 and 43 years in age without recurrence after tumor resection. The tumors were Larger in size, diameter 5cm and 8cm, all encapsulated and solid. Histologically a uniform population of cell was seen. The nuclei were oval, round without alypia, and rate of mitotic activity was evident, the tumor cell was characterized by abundant oxyphilic cytoplasm, differential diagnosis hurthle carcinoma with capsular and vascular invasion. Immunostains showed that almost all benign and malignant HCT expressed TG, vimentin, S-100 protein, CEA positive staining was seen in most Hurthle cell adenomas and carcinomas. Conclusion The clincopathological and immunohistochemical features of the thyroid HCT are similar to their counterpart of the thyroid.
出处
《中国现代医生》
2008年第1期44-45,共2页
China Modern Doctor
关键词
甲状腺
嗜酸细胞性腺瘤/癌
包膜
鉴别诊断
Thyroid
Hurhle cell adenoma/carcinoma
Capsulation
Differential diagnosis
