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外源性雄激素对EAE大鼠血中CD4^+CD25^+T细胞的影响 被引量：3

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摘要 目的探讨外源性雄激素对实验性自身免疫性脑脊髓炎(experimental allergic encephalomyelitis,EAE)大鼠外周血CD4+CD25+T的影响。方法模型组用豚鼠脊髓和完全弗式佐剂混匀乳剂诱发大鼠EAE,治疗组在模型组的基础上给予外源性雄激素,观察各组的发病情况;流式细胞仪检测外周血CD4+CD25+T细胞;HE染色和髓鞘染色分别观察病理和髓鞘改变。结果治疗组的CD4+CD25+T细胞(5·3±0·90)较模型组(6·5±0·90)显著增高(P<0·01),大脑、脑干、脊髓炎性细胞浸润明显减少,髓鞘的改变不明显。结论外源性雄激素可能通过改变了CD4+CD25+T细胞的水平,而对EAE起一定的治疗作用。
作者 李婛 曾丽 邹东华
机构地区 广西医科大学第一附属医院神经内科
出处 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2008年第2期115-117,共3页 Chinese Journal of Nervous and Mental Diseases
基金 广西科学基金项目(编号:0542088)
关键词 CD4^+CD25^+T细胞 实验性自身免疫性脑脊髓炎 外源性雄激素
分类号 R744.5 [医药卫生—神经病学与精神病学]
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参考文献9

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同被引文献26

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中国神经精神疾病杂志
2008年 第2期

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