摘要
目的探讨画钟测验(clock drawing test,CDT)对识别轻度血管性认知障碍(mild vascular cognitive impairment,mVCI)和轻度血管性痴呆(mild vascular dementia,mVD)患者的敏感度和特异度。方法mVCI患者80例,mVD患者30例,正常对照80名。由独立的神经心理评估医师盲法检测CDT,采用3分法、阿尔茨海默病协作研究组方法(AD cooperative study)和Rouleau方法进行评分,并进行简易精神状态(mini-mental state examination,MMSE)及其他量表的检测。应用操作者特征性曲线(receiver operating characteristic curve,ROC)确定3种评分方法的CDT对区别mVCI和正常对照以及mVD与正常对照的敏感度和特异度。结果3组间在年龄、性别和教育程度上匹配。在区别mVCI和正常对照中,3种评分方法CDT的敏感度分别为63·7%、65·0%、68·7%,特异度分别为87·5%、86·2%、78·7%。3种评分方法的CDT对区别mVD和正常对照均有较高的敏感度(90·0%、90·0%、83·3%)和特异度(87·5%、86·2%、95·0%)。结论对识别mVD,CDT是一种有效的筛查手段;但是对识别mVCI,CDT的作用有限。
Objective To determine the validity of the clock drawing test （CDT） in differentiating mild vascular cognitive impairment （mVCI） patients and mild vascular dementia （mVD） patients from normal subjects. Methods Eighty mVCI patients, 30 mVD patients, and 80 normal control subjects were comprehensively evaluated with mini-mental state examination （ MMSE）, CDT and other tests. CDT was blindly scored by independent clinical psychclogists according to three methods： the three point method, the AD Cooperative Study method, and the Rouleau method. The sensitivities and specificities of the three CDT measures for identifying the two patient groups from normal controls were determined using the receiver operating characteristic curve （ROC）. Results The three groups matched in demographic characteristics. In differentiating between mVCI and normal subjects, the three CDT measures provided a sensitivity of 63.7%, 65.0%, and 68. 7%, and a specificity of 87.5%, 86. 2%, and 78.7% respectively. All the three CDT measures showed good validity in identifying mVD from normal controls （ sensitivity 90.0%, 90. 0%, 83.3% ; specificity 87.5%, 86. 2%, 95.0% ）. Conclusions Though CDT is valid in screening for mVD, it is not a reliable instrument in screening mVCI.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2008年第2期72-75,共4页
Chinese Journal of Nervous and Mental Diseases
关键词
画钟测验
轻度血管性认知障碍
轻度血管性痴呆
敏感度
特异度
Clock drawing test Mild vascular cognitive impairment Mild vascular dementia Sensitivity Specificity
