摘要
目的对性激素受体在脑膜瘤发生发展中的作用进行分析。方法对手术切除标本进行病理组织分类和性激素受体的测定,检测脑膜瘤患者术前瘤周水肿情况,并对它们之间的关系进行分析。结果脑膜瘤患者的孕激素受体(PR)和雄激素受体(AR)在脑膜瘤中有较广泛的表达,其表达与细胞类型有关。其中PR与瘤周水肿存在相关关系,而AR与PR无相关关系。结论性激素可通过脑膜瘤中广泛存在的PR与AR起作用,而其中起主导作用的可能是PR。
Objective To analyze the function of sexual hormones receptors in the oneogenesis of meningioma. Methods We detected the degree of the peri-tumor edema of meningioma patients before operations. Then intracranial meningiomas from 40 patients were immunohistochemically evaluated for sexual hormone receptors using specific monoclonal antibodies; at the same time, the histological subtypes and tumor grades were determined. The relationships between them were analyzed. Resulta The result of immunohistochemistry illustrated that PR and AR expressed widely in meningioma and the quantity was related with the histological subtypes. Additionally, significant correlation between PR and peri-tumor edema was detected.Conclusion From all of the data in our experiments, it is reasonable for us to assume that the sexual hormones especially PR can interact with the corresponding receptors, which have been shown to widely express in meningiomas.
出处
《云南医药》
CAS
2008年第1期14-16,共3页
Medicine and Pharmacy of Yunnan
