摘要
应用米托蒽醌（MTZ）为主的联合化疗方案，治疗成人难治性急性白血病25例，急非淋21例，急淋4例。结果完全缓解率48％，部分缓解率30％，总有效分80％。MTZ的主要毒副作用为严重的骨髓抑制及一过性肝功能损害等。结果表明：MTZ为主的联合化疗方案对于成人难治性急性白血病具和疗效高、副反应小的优点。
Twenty-five adult patients with refractory acute leukemia were treated with mitoxantrone (MTZ ) in combination with other chemotherapeutic agents.Complete remission was abtained in 12 of 25 patients (48% ). Partial remission was achieved in 8 patients (32% ). Total response rate was 80%. The major toxicity of MTZ was bone marrow suppression and transient hepatic dysfunction. The resultsindicated that MTZ in combination therapy seemed to be an effective therapy for treatment of refractory acute leukemia with less toxicity.
出处
《临床血液学杂志》
CAS
1997年第3期101-103,共3页
Journal of Clinical Hematology
