摘要
目的观察安理申(盐酸多奈哌齐)联合克林澳(马来酸桂哌齐特)治疗早期血管性痴呆的临床疗效。方法100例血管性痴呆患者随机分为两组,治疗组50例采用安理申5mg每晚临睡前口服,共治疗4周。另给予克林澳注射液160mg加入生理盐水250mL中静滴,每日1次,共2周。对照组50例采用安理申5mg每晚临睡前口服,共治疗4周。治疗4周前后评价简易智能精神状态评估量表(MMSE)、日常生活功能量表(ADL)、长谷川痴呆量表(HDS)、痴呆严重程度临床评定量表(WMS)、TCD的变化。将结果进行统计学处理。结果治疗组治疗后MMSE、ADL、HDS、WMS评分和TCD及脑动脉血流较对照组均有明显改善,差异有统计学意义(P<0.05)。治疗组治疗前后评分及TCD亦有显著改善,差异有统计学意义(P<0.05)。结论安理申联合克林澳治疗早期血管性痴呆疗效显著,优于单独使用安理申。
Objective To investigate the efficacy of aricept combined by cinepazide maleate in the treatment of vascular dementia （VaD）. Methods One hundred patients with VaD were divided randomly into 2 groups,the treating group was treated with aricept 5mg/d for 4 weeks,combined by cinepazide maleate 160mg/d for 2 weeks; the control group was only treated with aricept 5mg/d for 4 weeks. After treating for 4 weeks, the score of MMSE, ADL, HDS, WMS and TCD were evaluated and treated statistically in both groups before and after treatment. Results The score of MMSE,ADL, HDS,WMS and TCD and blood stream of cerebral arteries were obviously improved in the treating group than that in the control group. There was significant difference between the two groups（P〈0.05 ）. There was significant difference pre-and post-treatment in the treating group（P〈0.05）. Conclusion Aricept combined by cinepazide maleate has better efficacy than single aricept in the treatment of VaD.
出处
《重庆医学》
CAS
CSCD
2008年第5期498-499,501,共3页
Chongqing medicine
