摘要
以异丁醛和甲醛为原料,三乙胺为催化剂,羟醛缩合法合成了2,2-二甲基-3-羟基丙醛。考察了物料比、加料方式、反应温度和反应时间对反应结果的影响,同时考察了产品的分离精制工艺。在物料比n(异丁醛)∶n(甲醛)∶n(三乙胺)为1∶1.1∶0.02、反应温度61～65℃的优化反应条件下,反应4～5h,所得产品经水洗、减压、蒸馏和结晶后,2,2-二甲基-3-羟基丙醛收率达到95%,纯度为99%以上。
The preparation of 2,2-dimethy1-3-hydroxy propanal from the condensation of formaldehyde and ibutyraldehyde by using triethylamine as catalyst was studied. The main effect factors, ratio of materials, charging-up mode, reaction time and reaction temperature were examined. The obtained reaction optimum conditions were as follows： n （i- butyraldehyde）：n（formaldehyde）：n（triethylamine） =1： 1.1：0.02, 61-65℃, 4-5 h. Under above reaction conditions, and after purification, the yield and purity of product reached 95% and more than 99%, respectively.
出处
《精细化工中间体》
CAS
2008年第1期44-46,共3页
Fine Chemical Intermediates
