摘要
本文测定了不同运动条件下的大鼠骨骼肌中的雄激素受体（ａｎｄｒｏｇｅｎｒｅｃｅｐｔｏｒ，ＡＲ）结合容量及雄激素的水平。一次力竭运动可使大鼠股四头肌组织的雄激素结合容量水平上升，但降低了其组织中的雄激素水平。在长期力竭性运动后，股四头肌组织雄激素受体结合容量及雄激素水平均没有变化，而长期的适宜运动则可提高股四头肌的雄激素结合容量的水平，但对其雄激素的水平仍无影响。通过机体注射ＨＣＧ（人促绒毛膜性腺激素），可提高骨骼肌组织的雄激素水平，但骨骼肌雄激素受体结合容量水平没有变化。连续注射ＨＣＧ４天，其骨骼肌组织雄激素水平显著高于连续注射ＨＣＧ８天的水平。根据上述结果，我们认为，在考虑骨骼肌同化过程时，不但要注意其雄激素的水平，还应注意其雄激素受体的水平。
Androgen receptor (AR) binding and testosterone (T) level of skeletal muscle of rat at the different conditions were observed in this study. The exhausted exercise could up regulate the AR binding of levator ani muscle, but decrease the T level in quadriceps. The long term exhausted exercise had no effect on the AR binding of quadriceps. The fitness exercise could up regulate the AR binding of quadriceps but have no significant effect on the T level in quadriceps. There was no effect on the AR binding but T level was increased after injection of HCG for 4 days in quadriceps . The increase of T level in skeletal muscle after injection of HCG for 4 days was higher than that for 8 days. From these results it is suggested that the effect of exercise on the regulation of hormone on skeletal muscle may be in two directions. Both AR binding capacity and T level must be considered in skeletal muscle anabolism.
出处
《中国应用生理学杂志》
CAS
CSCD
1997年第3期198-201,共4页
Chinese Journal of Applied Physiology
关键词
运动生理学
雄激素
雄激素受体
骨骼肌
Testosterone
Androgen receptor
metabolism
regulation
muscle
exercise
