摘要
目的:观察奈达铂(Nedaplatin,NDP)联合其他化疗药治疗头颈部癌、食管癌及非小细胞肺癌的临床疗效及其不良反应。方法:本组14例患者均经病理或细胞学、影像学所证实,其中初治4例,复发10例。初治4例中,鼻咽癌2例、舌癌1例、牙龈癌1例;复发的10例中,非小细胞肺癌4例、食管癌3例、鼻咽癌3例,按1997年国际抗癌联盟(UICC)的临床恶性肿瘤分期(TNM分期)法进行分期,所有患者均为Ⅳ期。结果:运用含NDP的化疗方案治疗头颈部肿瘤、非小细胞肺癌、食管癌的有效率分别为57.14%、25.00%、33.30%。不良反应方面,Ⅱ度以上的白细胞下降和血小板下降分别为42.86%、胃肠道反应中恶心50.00%、呕吐35.71%,而Ⅱ度以上肾功能损害发生率仅为12.50%。结论:含奈达铂的化疗方案具有一定的临床疗效,胃肠道反应、肾脏毒性轻。
OBJECTIVE： To evaluate the therapeutic effect and the toxic reaction of Nedaplatin （NDP） combined with other chemo- drugs in the treatment of advanced carcinoma. METHODS： A total 14 patients who had been confirmed as having advanced cancer by pathology or cytology and imaging were enrolled, of whom, 4 were initial treatment eases and 10 recurrent eases. Of the 4 initial eases, 2 were with nasopharyngeal carcinoma （NPC）, 1 tongue cancer and 1 carcinoma of gingival. Of the 10 recurrent eases, 4 were with NSCLC, 3 esophageal carcinoma and 3 NPC. All the patients were at TNM stage Ⅳ based on the TNM staging recommended by International Union Against Cancer （UIAC） . RESULTS： The effective rates of NPD - contained chemotherapy for head ＆ neck cancer, NSCLC and esophageal carcinoma were 57.14%, 25.0% and 33.3%, respectively. As for the major toxic reactions, the rate of patients with reductions （above grade Ⅱ ） of WBC and blood platelets was 42.86%; in terms of gastrointestinal tract reaction, 50% showed nausea and 35.71% vomiting while only 12.5% showed renal function damage （above grade Ⅱ ）. CONCLUSION： NDP used concurrently with other chemo - drugs was proved to be of certain efficacy in advanced carcinoma patients while the gastrointestinal tract reaction and nephrotoxicity induced by which is mild.
出处
《中国医院用药评价与分析》
2008年第1期49-51,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
鼻咽癌
食管癌
非小细胞肺癌
奈达铂
不良反应
Nasopharyngeal carcinoma （NPC）
Esophageal carcinoma
Non - small - cell lung cancer
Nedaplatin （NDP）
Adverse effects
