摘要
用聚乙二醇(PEG)修饰异黄酮类化合物(1)的侧链,并采用不同氨基酸做连接臂,合成了聚乙二醇-异黄酮复合物——聚乙二醇-异黄酮酯前药(6),其结构经1H NMR和IR表征。在磷酸缓冲溶液中,1能在10 h内释放完全;6的载药量有待进一步提高。
Poly （ethylene glycol） -isoflavone complexes, poly （ethylene glycol） -isoflavone ester prodrugs （6）, were synthesized by modifying side chain radical of isoflavone （ 1 ） with PEG using different amino acids as the join-arm between 1 and PEG. The structures of 6 were confirmed by ^1H NMR and IR. The results showed that 1 was released completely from 6 in 10 h in phosphonic acid buffer solution. The loading amout of 1 on 6, which was comparatively lower, need to be further improved.
出处
《合成化学》
CAS
CSCD
2008年第1期77-80,95,共5页
Chinese Journal of Synthetic Chemistry
基金
浙江省医药卫生科学研究基金资助项目(2004B024)
关键词
异黄酮
聚乙二醇
前药
合成
isoflavone
poly（ ethylene glycol）
prodrug
synthesis
