摘要
目的:观察运动训练能否促进大鼠局部脑缺血再灌注后的神经功能恢复,并且观察早期运动训练对脑缺血再灌注后梗死体积的影响,从而探讨其促进功能恢复的机制。方法:成年雄性SD大鼠24只,随机分成运动训练组、对照组和假手术组,每组8只。大脑中动脉闭塞(MCAO)法造模24h后,运动训练组给予跑台训练,每天30min,连续训练2周,对照组及假手术组给予相同的抓取和固定。采用神经行为学评分评价造模情况及神经功能的恢复情况;甲苯胺蓝染色观察大鼠局部脑缺血再灌注后梗死体积的大小。结果:2周后,运动训练组的神经行为学评分明显高于对照组(P<0.05),并低于假手术组(P<0.05);运动训练组的脑梗死体积明显小于对照组(P<0.05)。结论:脑缺血再灌注后早期运动训练能够减小脑梗死体积,促进脑缺血大鼠神经功能的恢复。
Objective：To investigate whether physical training can improve neurological function and reduce the infarct volume after focal cerebral ischemia. Method：Twenty-four male adult Spragne-Dawley rats （2-3month old） were subjected to 60 mins right middle cerebral artery occlusion（MCAO）. All rats were randomly assigned to one of the three groups： physical training group, control group and sham operation group. Physical training group underwent 30 mins treadmill training per day for 2 weeks 24h after MCAO procedure. Result：After two weeks, the neurological score in physical training group was higher than those underwent spontaneous recovery （P〈0.05）.The infarct volume in physical training group was smaller than the controls （P〈0.05）. Conclusion： Physical training can improve neurological function and reduce the infarct volume after focal cerebral ischemia and reperfusion.
出处
《中国康复医学杂志》
CAS
CSCD
北大核心
2008年第2期100-102,共3页
Chinese Journal of Rehabilitation Medicine
基金
复旦大学基础和临床交叉基金(校200681)
上海市长宁区卫生局科研基金资助项目(2004104001)
关键词
脑缺血再灌注
运动训练
梗死体积
cerebral ischemia and reperfusion
physical training
infarct volume
