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细菌内毒素的致病机制及临床意义 被引量:3

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摘要 细菌内毒素的研究已有200多年的历史,早在18世纪有人将腐烂的鱼或肉中的液体经静脉注射到动物体内,发现能使动物发热,故称其为“致热物质”。1892年,Pfeiffer发现了细菌崩解时逸散出的内毒素。不久,Coley用以医治恶性肿瘤的Coley毒素组分被Shear证明为细菌内毒素。20世纪50年代后,人们逐渐认识到从这些革兰阴性菌分离得到的物质实际上为同一种成分即所有革兰阴性菌细胞壁外膜上的主要结构成分,对细菌的生长和活力至关重要,并将这些物质统称为内毒素或脂多糖(LPS)。
出处 《中国基层医药》 CAS 2008年第1期160-161,共2页 Chinese Journal of Primary Medicine and Pharmacy
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参考文献13

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共引文献44

同被引文献58

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