摘要
目的检测冠心病患者血浆内皮脂肪酶(EL)水平,探讨EL与冠心病的相关性。方法选取81例冠心病患者,并根据临床表现分为稳定性心绞痛(SAP)(n=18)、不稳定性心绞痛(UAP)(n=23)、急性心肌梗死(AMI)(n=21)及对照组(n=19)。所有患者分别进行病史采集,并检测空腹血糖(FBG)、血脂、高敏C反应蛋白(hs-CRP)、EL水平,分析EL与年龄、性别、吸烟比例、HDL-C、LDL-C、FBG、hs-CRP及冠状动脉病变程度的相关性。结果对照组血浆EL水平为(346.4±54.3)μg/L,而SAP组、UAP组、AMI组分别为:(693.2±89.7)μg/L、(780.3±99.2)μg/L(、962.5±123.3)μg/L,各组间EL水平比较差异有统计学意义(P<0.05);EL与HDL-C、LDL-C、FBG及hs-CRP明显相关(P<0.05);Gensini评分SAP组分别与UAP组、AMI组比较,差异有统计学意义(P<0.01),冠心病组EL平均水平与冠状动脉狭窄程度Gensini平均评分呈正相关(r=0.483,P<0.01)。结论冠心病患者体内EL表达明显增高,EL在冠心病的发生中可能起一定的作用。
Objective To investigate the correlation between plasma endothelial lipase （EL） level and coronary heart disease （CHD）. Methods A total of 81 patients were enrolled and divided into four groups： stable angina pectoris group （SAP, n=18）, unstable angina pectoris group （UAP, n=23）, acute myocardial infarction group （AMI, n=21） and control group （n=19）. Clinical history was collected and fasting blood glucose（FBG）, highdensity lipoprotein-cholesterol （HDL-C）, low-density lipoprotein-cholesterol （LDL-C-）, high sensitive-C reactive protein（hs-CRP） levels were determined. Relevance of EL to age, sex, smoking proportion, HDL-C, LDL-C, FBG, hs-CRP levels and coronary lesion was analyzed. Results Plasma EL level was （346.4±54.3） μg/L in the control group, （693. 2±89. 7） μg/L in SAP group, （780. 3±99.2）μg/L in UAP group and （962. 5±123.3）μg/L in AMI group. The differences among the four groups were statistically significant （P 〈0.05 ）. Significant correlation between EL level and HDL-C, LDL-C, FBG and hs-CRP levels were found （all P〈0.05）. Gensini scoring of SAP group was significantly different from the other three groups （all P〈0.05）. There was positive correlation between EL level and coronary lesion （r= 0. 483 P〈0.01）. Conclusions EL expression is increased in CHD patients. EL might play an important role in the genesis of CHD.
出处
《中国心血管杂志》
2008年第1期14-16,20,共4页
Chinese Journal of Cardiovascular Medicine
关键词
内皮脂肪酶
冠心病
Endothelial lipase
Coronary heart disease
