摘要
为探讨球囊房隔造口术（ＢＡＳ）及前列腺素Ｅ１（ＰＧＥ１）对婴儿完全性大动脉转位（ＴＧＡ）外科根治术前血液动力学的调整作用，对３２例年龄２～５６天，平均２６天的ＴＧＡ患儿行ＢＡＳ，对其中１１例于ＢＡＳ前给予ＰＧＥ１，然后进行血液动力学观察。结果：ＢＡＳ后动脉血氧饱和度（ＳａＯ２）由０．５３±０．１４上升至０．７４±０．１１。３０例患儿左右心房压差均＜０．２７ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）。单纯ＴＧＡ术后２４个月内左室压力＜５．３０ｋＰａ。ＰＧＥ１应用后ＳａＯ２由术前０．６０±０．１９上升至０．８６±０．０５。心导管检查测得左右室压力比为０．８６。提示，ＢＡＳ和ＰＧＥ１的应用可缓解新生儿ＴＧＡ低氧血症及维持其左右心室良好的压力比值。
The study was designed to understand the effects of balloon atrial septostomy (BAS) and prostaglandin E 1 (PGE 1) infusion on infants with complete transposition of great arteries before corrective surgery. After BAS was performed on 32 cases at an average age of 26 days and PGE 1 administered in 11 of them, the hemodynamics were observed in these patients. It was found that BAS resulted in a significant increase in arterial oxygen saturation (SaO 2) from 0 53±0 14 to 0 74±0 11 ( P < 0.001), with a decreased pressure gradient between left and right atria less than 0.27 kPa and left ventricular systolic pressure less than 5.3 kPa within 24 months in simple TGA. The arterial SaO 2 increased from 0.60±0.19 to 0.86±0.05, with a ratio of left to right ventricular systolic pressure more than 0.86 after PGE 1 infusion before BAS. The study indicates that, after BAS infants with TGA can survive until an appropriate age for atrial switch operation, and PGE 1 adminstration can relieve hypoxemia and keep a satisfactory ratio of left to right ventricular pressure for arterial switch procedure in the newborns with TGA.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1997年第7期371-373,共3页
Chinese Journal of Pediatrics
基金
卫生部基金
