摘要
光线性角化病的病理组织学特征为不同程度的表皮细胞的非典型增生。为了更加客观地反映该病的这一特征,应用流式细胞技术定量分析了27例光线性角化病皮损细胞的DNA含量及细胞增殖活性。结果:光线性角化病细胞的增殖指数(PI)高于正常人皮肤的PI值(P<0.05),8例非典型增生严重的光线性角化病细胞的DNA指数(DI)高于其余19例光线性角化病的DI值(P<0.05)。提示:光线性角化病皮损细胞增殖活跃,细胞非典型增生程度越高,DNA含量异常越明显。
Actinic keratosis (AK) is a precancerous state of the skin, which shows epidermal dysplasia of different degrees. The cellular DNA content and proliferative activity of the skin lesions in 27 cases of AK were analyzed with flow cytometry. The results showed that the PI (proliferating index) in AK was higher than that in normal skin (P<0.05). Among 27 eases of AK, the cellular DI (DNA index) of 8 cases of severely dysplastie AK was higher than the rest 19 cases (P<0.05). The results suggest that the cells in the skin lesions of AK proliferate actively, and the higher the degree of dysplasia showed in AK the more the significance of aberration of DNA content.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1997年第4期246-247,共2页
Chinese Journal of Dermatology
