摘要
对153名二氧化硅粉尘作业工人（接尘组）和84名年龄相当但不接尘及其它毒物者（对照组）肾功能进行调查。结果发现接尘工人尿NAG活性及尿α1－MG、β2-MG、A1b含量较对照组显著升高，且随接尘工龄延长而明显升高，呈剂量-反应关系。若以超过对照组95％单侧上限值为阳性标难，则尿α1－MG、β2-MG、A1b、NAG阳性率增高有显著意义，且尿酶与尿蛋白各指标之间呈正相关关系。表明长期接触含游离二氧化硅的粉尘除可引起呼吸系统功能损害外，尚可导致肾小球和肾小管的混合性损伤。提示尿α1－MG、β2-MG、A1b、NAG测定可作为矽尘所致慢性肾损害的敏感检测指标。
The relationship between renal alteration and silica exposure was observed. 153 silica exposedworkers and 84 unexposed healthy subjects as controls were investigated. The results showed thatthe levels of urinary α1-microglobulin (α1-MG), β2-microglobulin (β2-MG),albumin (A1b) and Nacetyl - β-D-glucosaminida se (NAG) in the exposed group were significantly higher than those of thecontrols. They increased progressively with the increase of the working-age. If the value>95% ofthat found in the controls was taken as the criterion for significance,the abnormal prevalence ofurinary α1-MG, β2-MG , A1b, NAG in the exposed group was significantly increased. The relationship between urinary NAG and urinary α1-MG, β2-MG, A1b, showed positive correlation(P<0.001). It is suggested that the silica dust not only could lead to lung damage,but also mightcause a mixed proximal tubular and glomerular dysfunction, Changes of urinary α1-MG,β2-MG,Alb,NAG might be taken as valuable indices for early detection of chronic subclinical renal dysfunctionin silica exposed workers.
出处
《工业卫生与职业病》
CAS
CSCD
1997年第4期205-209,共5页
Industrial Health and Occupational Diseases
关键词
二氧化硅
粉尘
尿酶
尿微量蛋白
肾损害
Silica dust
Renal dysfunction
Urinary enzyme
Urinary mcroglobulin
