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氧化应激参与脓毒症过程的研究进展及其对治疗的启发 被引量：4

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摘要 尽管生物技术和医疗干预手段日益先进，但脓毒症仍是住院病人死亡的重要原因。一方面，脓毒症过程信号调控机制复杂，应用一两种细胞因子或其抗体无法实现对多条信号通路的调控，一度被寄以重望的信号转导通路单靶点干预在多数临床试验中结果令人失望。另一方面，失控性炎症反应解释不了脓毒症的全部，现在认识到脓毒症存在免疫抑制和激活并存。近20年来，免疫学和细胞分子生物学方面的研究揭示了氧化应激对脓毒症过程的积极参与。于是能否针对氧化应激找到多靶点作用的药物，是这些研究带给我们的启示。
作者 徐志宏 施小燕
机构地区 浙江大学医学院附属第二医院ICU 宁波市第一医院ICU
出处 《中华急诊医学杂志》 CAS CSCD 2008年第2期221-223,共3页 Chinese Journal of Emergency Medicine
关键词 氧化应激 脓毒症 信号调控机制 失控性炎症反应 细胞分子生物学 多靶点作用 治疗 信号转导通路
分类号 R459.7 [医药卫生—急诊医学]
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参考文献27

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共引文献22

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引证文献4

二级引证文献9

中华急诊医学杂志
2008年 第2期

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