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周剂量紫杉醇联合卡铂治疗晚期非小细胞肺癌25例分析

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摘要 目的:观察周剂量紫杉醇联合卡铂治疗晚期非小细胞肺癌的近期疗效和毒副反应。方法:晚期非小细胞肺癌患者25例,治疗方案为:紫杉醇80 m g/m2,卡铂(曲线下面积为2)第1、8、15天给药,4周为1个周期,共6个周期,根据患者的毒性反应调整剂量及疗程,至少治疗2周期评价疗效。结果:CR 2例,PR 15例,NC 4例,PD 4例。紫杉醇的总有效率为68%(17/25)。主要毒副反应为血液学毒性,血液学毒性主要为白细胞减少,多为Ⅰ-Ⅱ度,共7例,占28%;Ⅲ度1例,占4%;Ⅳ度0例,占0%。血红蛋白下降2例(8%),血小板下降3例(12%),均为Ⅰ-Ⅱ度。非血液学毒性较轻微。无化疗相关性死亡。结论:周剂量紫杉醇联合卡铂方案治疗晚期非小细胞肺癌疗效好,毒副反应轻。
作者 吕巧妹
出处 《中国误诊学杂志》 CAS 2008年第7期1704-1705,共2页 Chinese Journal of Misdiagnostics
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