摘要
目的探讨薯蓣皂苷对2型糖尿病合并颈动脉粥样硬化患者脑血流供应状况的影响。方法69例T2DM患者在通过严格降糖、活血等一系列综合治疗基础上随机分治疗组35例,加薯蓣皂苷480mg,3次/日,口服。对照组34例原治疗不变。共观察2年,记录患者自觉症状,血流变,血脂,双侧颈总、椎动脉内膜厚度及颅内各血管的血流速度、搏动指数等指标的转归并加以分析。结果治疗组症状及上述指标改善均优于对照组(P<0.05),同时未发现明显毒副作用。结论薯蓣皂苷可延缓糖尿病患者动脉粥样硬化的进程,能改善大脑血流,是治疗和预防糖尿病合并动脉硬化患者的有效药物。
Objective To investigate the effects of dioscornin on cerebral blood flow of the patients with type 2 diabetes （T2DM） and arteriosclerosis of carotid artery. Methods 69 patients were randomly divided into two groups. The patients received treatment of controlling blood sugar and promoting blood flow in 2 years. 35 cases in treatment group were treated with dioscornin tablet （480mg, three times per day） and 34 cases in control group were treated by former measure. The symptom, hemorrheology, lipoid, IMI of double side of common carotid artery and vertebral artery, mean flow velocities （Vm） and pulsatility index （PI） of cerebral arteries in patients were recorded and analyzed. Results The symptoms and other index of treatment group were improved significantly （ P 〈 0.05） than those of control group, Treatment group were not discovered evident toxic effect. Conclusion Dioscomin can improve cerebral blood flow, and being effective medicine which can treat and prevent diabetes with arteriosclerosis.
出处
《宁夏医学杂志》
CAS
2008年第2期144-146,共3页
Ningxia Medical Journal
