摘要
目的观察改变七叶皂苷溶液的pH值是否可以改善七叶皂苷所致的静脉炎（静脉刺激）发生率。方法选取静脉注射七叶皂苷治疗的患者共43例，随机分为两组。其中缓冲液组使用20mg七叶皂苷溶于5％葡萄糖注射液500ml中，同时在配液时加入1ml 5％碳酸氢钠缓冲液，将溶液pH值调至7．4左右；常规组仅将20mg七叶皂苷溶于5％葡萄糖注射液500ml中，pH值约为4．6，不加入碳酸氢钠进行中和。两组患者均接受每日1次七叶皂苷静脉输液治疗，连续治疗7d。使用INS静脉炎分级和统计标准，对两组患者静脉炎的发生率进行比较。结果缓冲液组的患者各级静脉炎的发生率为9．1％，常规组静脉炎的发生率为21．8％，两组比较差异有统计学意义（P〈0．01）。结论配液时在七叶皂苷溶液中加入1ml 5％碳酸氢钠缓冲液将溶液pH值调至7．4左右，可以显著减少七叶皂苷导致的静脉炎发生。
Objective To observe whether changing the pH value of the aescin solution would alter the incidence of aescin-induced phlebitis. Methods Forty-three patients,33 males and 10 females to take aescin infusion treatment after taking orthopedic surgeries,were randomly assigned into two groups. The two groups were taken different methods to prepare the aescin solutions. One method of preparing the aesein solution was to resolve 20 mg aesein in 500 ml 5% dextrose solution and inject 1 ml 5% of sodium bicarbonate as well, which adjusted the pH value of the aesein solution to about 7.4. The other group didn＇t use any sodium bicarbonate while other conditions were the same, whose pH value of the solution was about 4.6. Patients in both the groups acceped the aescin treatment once daily continuously for 7 days. Standard of INS was used to count the incidence of phlebitis. Results Incidence of phlebitis in the group who accepted the sodium bicarbonate buffered solution was 9.1%. The phlebitis rate in the non-sodium bicarbonate-buffered aescin solution group was 21.8%. The difference between the two groups was statistically significant （P 〈 0.01 ）. Conclusion Increase the pH value of the aescin solution to the level of about 7.4 by adding 1 ml 5% of sodium bicarbonate could significantly reduce the aescin-induced phlebitis.
出处
《中国医师进修杂志》
2008年第2期26-28,共3页
Chinese Journal of Postgraduates of Medicine
关键词
静脉炎
碳酸氢钠
七叶素
氢离子浓度
Phlebitis
Sodium bicarbonate
Escin
Hydrogen-ion concentration
