摘要
目的：探讨小肝癌切除术后影响预后的有关因素。方法：分析42例手术切除小肝癌的临床病理学特征。32例随访1～18年（中位数9年）结果示：1、3、5、10年生存率：3．1～5cm（18例）为88．9％、44．4％、22．2％及5．6％，2．1～3cm（9例）为100％、66．7％、33．3％及22．2％；≤2cm（5例）为80．0％、40．0％、40．0％及20．0％；总体生存率为90．0％、56．3％、28．1％及12．5％。1、3、5年复发率为：3．1～5cm为22．2％、61．1％及66．7％；2．1～3cm为0％、22.2％及22．2％；≤2cm为20．0％、40．0％及40.0％；总体复发率分别为15．6％、46．9％及50．0％。2．1～3cm组的5年复发率明显低于3．1～5cm组（P均＜0．05）。结论外肝癌术后患者应视为高危人群，并随访至10年。
Objectivs: The clinico-pathological features of 42 patients with resected small hepatocellular carcinoma(SHCC) were studied retrospectively from Jan 1977 to Jan 1995 in the hospital. Methods: Of the 42 patients, 32 were followed up for 1~18 yrs, with a median of 9 yrs.Results: The survival rates of SHCC≤5cm(n=18) at 1-,3-,5-,and 10-yrs were 88.9%, 44.4 %, 22.2% and 5.6%; ≤3cm(n=9),100%,66.7%, 33.3 % and 22.2 % ≤2cm(n=5),80.0%, 40.0%, 40.0% and 20.0%respcetively. The overall survival rate was 90.6%,56.3 %,28.1 % and 12.5 % respectively. The 1-,3-and 5-yrs recurrence rates in SHCC≤5cm were 22.2 %, 66.1 % and 66.7 %, ≤3cm,0.0%, 22.2% and 22.2 %;≤2cm, 20.0%, 40.0% and 40.0% respectively. The overall recurrence rate was 15.6%,46.9% and 50.0% respectively. Conclusions: The 5 yrs recurrence rate in case of ≤5cm was higher than that in ≤3cm(P<0.05).This indicates that the postoperative recurrence is still the main risk factor on prognosis. The grading of cirrhosis and its complications, encapsulation, size and number of the tumors and the extent of resection are also high risk factors influencing their prognosis. Second resection of recurrent lesions and enegetic treatment of cirrhotic complications may prolong the patients's survival period. Three of such patients with recurrent lesions treated by re-resection and ethanol injection therapy and one with repeated massive EVB after surgery and sclerotherapy were still alive for more than 8,10,16 and 18 years.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1997年第1期33-35,共3页
Chinese Journal of Digestion
关键词
肝肿瘤
生存率
复发
治疗
Liver neoplasm Survival rate Recurrence
