摘要
目的进一步了解溃疡性结肠炎（ulcerative colitis，UC）的发病特点。方法分析我院1998年至2006年间收治的138例经肠镜、病理学检查并结合临床症状而确诊的UC的临床特点。结果UC的发病以20—60岁者多见（108例，78．3％），病程小于1年者较多（63例，45．7％），轻中度多见（100例，72．4％），血便为最常见表现。红细胞沉降率、血红蛋白、白蛋白及α1、α2球蛋白水平与病情相关，血小板平均值居于正常值的上限。肠镜见病变部位以全结肠病变为主（78例，56．5％）。病理学检查均有炎症细胞浸润，慢性炎症者多见。大多数患者用柳氮磺胺吡啶和（或）5-氨基水杨酸治疗有效（70例，50．7％）。结论国内UC患者病情较轻，病程较短，并发症以及肠外表现很少，疾病临床特点尚比较典型。α1、α2球蛋白与本病有相关性。国内UC患者对于柳氮磺胺吡啶和（或）5-氨基水杨酸敏感。
Objective To investigate the clinical features of ulcerative colitis （UC）. Methods Based on typical clinical manifestation, enteroscopy and pathological results, 138 in-hospital patients were diagnosed UC during 1998 to 2006. Their clinical features were analyzed in this report. Results UC was more commonly seen in people aged 20 - 60 （ n = 108, 78.3% ）. Nearly forty-six percent of the patients （n =63, 45. 7% ） had the disease less than one year. More patients （n = 100, 72.4% ） showed mild or moderate UC. Bloody stool was the most common manifestation, erythrocyte sedimentation rate, hemoglobin, albumin and α1 or α2 globulin levels were closely related with the condition. The mean value of platelet counting was in the upper limit of the normal value. Enteroscopy found more lesion located in the whole colon （n =78, 56.5% ）. Pathological results showed infiltration of inflammatory cells, especially in patients with chronic inflammation. Salicylazosulfapyridine （SASP） and/or 5-Aminosalicyclic （5-ASA） were effective in most UC patients （ n = 70, 50. 7 % ）. Conclusions Chinese patients usually had mild to moderate UC, and their courses were often shorter than abroad. The disease was closely related with α1 and α2 globulin levels. Most of the patients had response to SASP and/or 5-ASA.
出处
《中华全科医师杂志》
2008年第2期97-99,共3页
Chinese Journal of General Practitioners
关键词
溃疡性结肠炎
诊断
治疗
Ulcerative colitis
Diagnosis
Therapy
