判断肝硬化门静脉高压预后模型的研究
Establishement of a model for predicting the prognosis in patients with liver cirrhosis
摘要
本研究拟建立一个判断肝硬化门静脉高压预后的新模型,探讨其预测价值。
一、资料与方法
1.研究对象:采用队列研究的设计方法,前瞻性分析106例确诊为乙型肝炎后肝硬化患者。患者均为汉族人,有乙型肝炎病史,乙型肝炎病毒标志物检测阳性,其他病毒标志物阴性,肝酶谱有不同程度的异常。无原发性心、肺、肾疾病及高血压病史。
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2008年第2期140-141,共2页
Chinese Journal of Hepatology
基金
广东省自然科学基金(A2004769)
关键词
肝硬化
高血压
门静脉
预后
Liver cirrhosis
Hypertension, portal
Prognosis
参考文献3
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1程元桥,林菊生,廖家智,梁扩寰,熊平.内皮型一氧化氮合酶基因多态性与肝硬化门静脉高压的相关性研究[J].中华医学杂志,2003,83(13):1116-1121. 被引量:3
-
2程元桥,林菊生,王文琦,熊平,姜晓丹.诱导型和内皮型一氧化氮合酶基因多态性与肝硬化门静脉高压的相关性[J].中华肝脏病杂志,2005,13(5):366-369. 被引量:1
-
3Botta F, Giannini E, Romagnoli P, et al. MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study. Gut, 2003, 52:134-139
二级参考文献16
-
1Kun J, Morduller B, Lell B, et al. Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against Malaria.Lancet, 1998, 351: 265-266.
-
2Yoon Y, Song J, Hong SH, et al. Plasma nitric oxide concentrations and nitric oxide synthase gene polymorphisms in coronary artery disease. Clin Chem, 2000, 46: 1626-1630.
-
3Colombo MG, Paradossi U, Andreassi MG, et al. Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem, 2003, 49: 389-395.
-
4Nakayama M,Yasue H,Yoshimura M, et al. T-786C mutation in the 5'flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation, 1999, 99:2864-2870.
-
5Wang XL,Sim AS,Badenhop RF, et al. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nature Med ,1996,2:41-45.
-
6Shimasaki Y,Yasue H, Yoshimura M, et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol, 1998, 31:1506-1510.
-
7Miller SA,Dykes DD,Folesky HF,et al. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res, 1988, 16:12-15.
-
8Niederberger M,Martin PY,Gines P,et al. Normalization of nitric oxide production corrects arterial vasodilatation and hyperdynamic circulation in cirrhotic rats. Gastroenterology, 1998,109:1624-1630.
-
9Zanchi A, Moczulski DK,Hanna LS,et al. Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney Int, 2000, 57:405-413.
-
10Salvarani C, Boiardi L, Casali B,et al. Endothelial nitric oxide synthase gene polymorphisms in Behcet′s disease. J Rheumatol,2002,29:535-540.
共引文献2
-
1吕东霞,刘劲阳,李岩,杨方,颜迎春,韩淑华,魏倪.肝硬化门静脉高压危险因素的分析[J].中国现代医生,2009,47(11):75-76. 被引量:2
-
2林菊生.重视肝硬化遗传易感性的研究[J].中华医学杂志,2003,83(13):1113-1115. 被引量:5
-
1丁蕊,马红,贾继东.肝硬化的分期、无创诊断、预后模型及治疗进展[J].传染病信息,2012,25(4):193-195. 被引量:5
-
2陈国庆.终末期肝病的预后模型评分与失代偿期肝硬化预后关系研究[J].中华实用诊断与治疗杂志,2012,26(6):615-616. 被引量:8
-
3杨方,魏倪.乙型肝炎肝硬化失代偿期预后因素分析及预后模型的建立[J].中华传染病杂志,2008,26(12):750-753. 被引量:5
-
4张俊勇,李宾,蒯景华.肝功能衰竭预后模型及其应用评价[J].山东医药,2009,49(7):108-109.
-
5张道杰,彭立义,权启镇,王要军.肝酶谱测定对汉防己甲素抗肝纤维化作用的价值分析[J].中草药,1996,27(2):93-95. 被引量:2
-
6林永泉,张春梅,荣丽华.有机磷农药中毒患者肝酶谱变化的研究[J].中西医结合实用临床急救,1998,5(5):206-208. 被引量:5
-
7林永泉,荣丽华.有机磷中毒对肝酶谱的影响及意义[J].劳动医学,1997,14(4):216-217.
-
8娄磊.阿司匹林及低分子肝素联合奥扎格雷抗栓治疗急性冠脉综合征的疗效及安全性[J].中国煤炭工业医学杂志,2011,14(11):1617-1618. 被引量:1
-
9基因表达谱使乳腺癌预后模型更准确[J].河南医学研究,2008,17(2):118-118.
-
10刘杰玉,冯义朝.多种肝衰竭预后模型的对比分析[J].临床肝胆病杂志,2014,30(10):1082-1086. 被引量:3