摘要
目的:测定非小细胞肺癌(non-small cell lung cancer,NSCLC)微血管计数(microvessel count,MVC)和间质炎性细胞肿瘤相关巨噬细胞(tumor associated macrophages,TAMs)和肥大细胞(mast cells,MCs)计数,探讨它们之间的相互关系及其对NSCLC的临床意义。方法:采用免疫组织化学ABC法测定40例NSCLC和10例正常肺组织石蜡切片标本中微血管(microvessel,MV),TAMs及MCs计数。结果:NSCLC组织中MV,TAMs和MCs计数明显高于正常对照组,并且随着NSCLC的T分期和临床分期的升高、淋巴结转移和远处转移的出现以及生存时间的缩短而呈现出相应的增高。TAMs和MCs计数与MVC间呈正相关。结论:TAMs和MCs可能相互协同共同促进肿瘤血管生成,并通过血管生成这一中心环节影响肿瘤的发展、侵袭、转移乃至预后。
Objective To detect tumor microvessel count（MVC）,tumor associated macrophage（TAM）and Mast cell（MC）counts,and to explore their correlation and the clinical significance in non-small cell lung cancer（NSCLC）.Methods Immunohistochemical staining（ABC method）was used to measure MVC and TAM and MC counts in 40 cases of NSCLC tissues and 10 cases of normal pulmonary tissues as contrast.Results The counts of microvessel,TAMs,and MCs in the NSCLC tissues were apparently higher than those of the normal tissues,and these counts increased with the development of T stage and clinical stage,metastasis of the tumor,and the reduction of the patient survival time.The positive correlation was showed among the counts of microvessel,TAMs,and MCs.Conclusion Tumor interstitial infiltrating inflammatory cells,TAMs and MCs can cooperatively promote the tumor angiogenesis,which associates with the development,invasion,metastasis and prognosis of NSCLC.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2007年第6期1037-1041,共5页
Journal of Central South University ：Medical Science
