摘要
目的对48例口腔鳞状细胞癌内的p53蛋白免疫表达与淋巴结状态之间的关系进行评价,并观察p53蛋白免疫表达是否会影响这种疾病的临床结果。方法48例样本接受外科手术并被分为两组:新辅助化疗24例及另外仅接受外科手术治疗24例。应用免疫组织化学技术检测p53蛋白表达。收集临床病理事项并分析患者的存活情况。结果以10%的细胞核被染色作为标准,则口腔癌患者的50%(n=24)p53过表达,p53免疫表达与淋巴结状态无关。通过生存分析,淋巴结状态或p53免疫表达/淋巴结状态的组合均与临床结果无关。在接受新辅助化疗患者中,p53与存活之间未显示出显著性关系,然而,在仅接受手术治疗者中,p53免疫表达与良好预后之间存在部分显著性关系(P=0.05)。结论尽管在p53对预后的影响上存在争议,我们的结果建议这一因子并不适合于评定口腔癌的预后。
Objective Aberrations of the p53 gene and overexpression of its protein are widely recognized markers of malignancy including oral squamous cell carcinomas. This study was performed to evaluate the relationship of immunoexpression of p53 protein in series of 48 squamous cell carcinomas of the oral cavity with lymph node status and to investigate whether immunoexpression of p53 protein might influence the clinical outcome of the disease. Methods Forty - eight cases underwent surgical operation were classified into 2 groups ： 24 cases with neoadjuvant chemotherapy and another 24 cases surgery alone. P53 protein expression was investigated by means of immunochemistry. Clinical and histopathologic data were gathered and the patient survival was analyzed. Results 50% of the oral carcinomas （ n = 24） over expressed p53, using a threshold of 10% stained ceil nuclei. There was a negative correlation of p53 immunoexpression with node status. In survival analysis, node status or p53 / node status was not associated with clinical outcome, p53 did not show significant association with survival in cases with neoadjuvant chemotherapy Whereas, in patients with surgery alone, p53 immunoexpression significantly correlated with favorable survival outcome （ P = 0.05）. Conclusion Even though there is controversy over the prognostic relevance of p53, our results suggest that the factor is not suitable to decide prognosis in oral cancer.
出处
《临床和实验医学杂志》
2008年第2期36-37,41,共3页
Journal of Clinical and Experimental Medicine
