摘要
目的探讨单纯性肥胖儿童血浆超敏C反应蛋白（hsCRP）及血清肿瘤坏死因子α（TNF-α）水平变化及临床意义。方法72例体重指数（BMI）≥25kg／m^2的单纯性肥胖儿童为肥胖组，28例BMI在18-23kg／m^2为对照组，测定并分析两组血浆hsCRP及血清TNF-α水平。结果肥胖组儿童血浆hsCRP为（4．23±2．03）mg／L，较对照组的（2．54±1．42）mg／L显著增高（P〈0．01）；肥胖组儿童血清TNF-α水平为（201．62±43．81）ng／L较对照组的（142．12±37．55）ng／L显著增高（P〈0．01）；肥胖组血浆hsCRP和血清TNF-α均与BMI呈正相关（r=0．32和r=0．73，P〈0．01）。结论肥胖儿童血液中hscRP和TNF-α水平均明显增高，高水平hsCRP和TNF-α可能是儿童肥胖的重要生物学标志之一。
Objective To study the correlation between obesity and hypersensitive C-reactive protein （hsCRP） and tumor necrosis factor-alpha （TNF-α） in children. Methods The subjects included 72 children with obesity [body mass index（BMI）≥25 kg/m^2] and 28 children with BMI 18- 23 kg/m^2. hsCRP and TNF-α were tested. The results between the obese and normal children were compared and the correlation between the parameters was evaluated. Results The levels of plasma hsCRP and serum TNF-α were significantly higher in obese children than those in normal controls （P〈0.01）. The levels of hsCRP and TNF-α were positively correlated with BMI（P〈0.01）. Conclusion hsCRP and TNF-α may participate in the pathogenesis of obesity, and may be taken as the biochemical markers of childhood obesity.
出处
《江苏医药》
CAS
CSCD
北大核心
2008年第2期142-143,共2页
Jiangsu Medical Journal
关键词
肥胖
超敏C反应蛋白
肿瘤坏死因子Α
Obesity
Hypersensitive C-reactive protein
Tumor necrosis factor-alpha
