摘要
为证实甲型肝炎（甲肝）密切接触者血白细胞中有无ＨＡＶ存在，采用间接免疫荧光法连续观察甲肝密切接触者的外周血白细胞中的ＨＡＡｇ，并对３例ＨＡＡｇ阳性者行甲肝病毒分离方法加以证实。结果表明３８例密切接触者中有２４例在观察期间出现血白细胞ＨＡＡｇ阳性，并分离到ＨＡＶ。提示在潜伏期，距黄疸发生１０天前即可在血白细胞中检测到ＨＡＡｇ，而相当部分的密切接触者呈隐性感染，表现为白细胞ＨＡＡｇ阳性，低滴度抗ＨＡＶＩｇＭ，而无肝炎症状和肝功能异常。
In order to verify whether there is HAV in the leucocytes from hepatitis A close contacts, we observed HAAg in the peripheral leucocytes from these people using indirect immunofluorescence and proved the results by isolating HAV from 3 close contacts with HAAg positive simultaneously. The results indicated that 24 out of 38 HA close contacts were HAAg positive. It suggested that HAAg can be detected in leucocytes 10 days before jaundice occured during incubation period. However, quite a few HA close contacts were subclinically infected with leucocytes HAAg positive and low dilution of anti HAV IgM, but without Hepatitis symptoms and liver function abnormalitis.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
1997年第3期148-150,共3页
Chinese Journal of Infectious Diseases
基金
军队"85"指令性课题
