腺相关病毒与类风湿关节炎的基因治疗
摘要
类风湿关节炎（rheumatoid arthritis，RA）是一种以关节炎症为特征的自身免疫性疾病，属多基因病。病因不清，但免疫和炎症反应过程已比较清楚。滑膜炎症不仅引起关节疼痛和肿胀，而且导致不可逆的骨和关节破坏。其病理生理学进展引进了靶向治疗的概念，例如瘤坏死因子（TNF）-α阻滞剂（如依那西普、英夫利昔单抗和阿达木单抗）、
出处
《中华风湿病学杂志》
CAS
CSCD
2008年第2期122-123,共2页
Chinese Journal of Rheumatology
基金
国家自然科学基金资助项目（30571885）
参考文献17
-
1Chirmule N, Propert K, Magosin S, et al. Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther, 1999, 6: 1574-1583.
-
2Goater J, Muller R, Kollias G, et al. Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis. J Rheumatol, 2000, 27: 983-989.
-
3Arai Y, Kubo T, Fushiki S, et al. Gene delivery to human chondrocytes by an adeno associated virus vector. J Rheumatol, 2000, 27: 979-982.
-
4Cottard V, Valvason C, Falgarone G, et al. Immune response against gene therapy vectors: influence of synovial fluid on adenoassociated virus mediated gene transfer to chondrocytes. J Clin Immunol, 2004, 24: 162-169.
-
5Cottard V, Mulleman D, Bouille P, et al. Adeno-associated virusmediated delivery of IL-4 prevents collagen-induced arthritis. Gene Ther, 2000, 7: 1930-1939.
-
6Apparailly F, Millet V, Noel D, et al. Tetracycline-inducible interleukin-10 gene transfer mediated by an adeno-associated virus: application to experimental arthritis. Hum Gene Ther, 2002, 13: 1179-1188.
-
7Zhang HG, Huang N, Liu D, et al. Gene therapy that inhibits nuclear translocation of nuclear factor kappa B results in tumor necrosis factor alpha-induced apoptosis of human synovial fibroblasts. Arthritis Rheum, 2000, 43: 1094-1105.
-
8Pan RY, Chen SL, Xiao X, et al. Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis Rheum, 2000, 43: 289-297.
-
9Chan JM, Villarreal G, Jin WW, et al. Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene product. Mol Ther, 2002, 6: 727- 736.
-
10Pan RY, Chen SL, Xiao X, et al. Disease-inducible transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model. J Virol, 1999, 73: 3410-3417.
-
1郑宏健,卢新政.心率增快的心血管病理生理学进展[J].心血管病学进展,2011,32(5):699-702. 被引量：8
-
2王丽娜,张磊,鄢盛恺,湛玉良.系统性红斑狼疮的遗传学研究进展[J].国际检验医学杂志,2011,32(1):62-64. 被引量：1
-
3张伊伟,叶发民,魏文启.支气管哮喘患者外周血IL-4、TNF-α测定及临床意义[J].临床医学,2005,25(4):81-82. 被引量：6
-
4刘巧红,沈凌汛,吴清敏.类风湿关节炎患者血清肿瘤坏死因子α、白细胞介素-6的检测及其临床意义[J].临床内科杂志,1998,15(6):307-308. 被引量：6
-
5郭继忠,占强,唐建英,邵力正.肝硬化患者血浆降钙素基因相关肽及肿瘤坏死因子-α水平的变化[J].中华消化杂志,2000,20(3):203-204. 被引量：5
-
6李虹伟,郭春艳.急性心力衰竭的病理生理学进展[J].中华老年多器官疾病杂志,2007,6(2):88-91.
-
7焦云根,祝宝华,何黎民,凤以良.肺炎衣原体在急性冠状动脉综合征中的意义及其致病机制[J].中国综合临床,2003,19(5):410-411. 被引量：1
-
8顼志敏,胡大一,马长生.PTCA治疗不稳定型心绞痛[J].国外医学（内科学分册）,1997,24(3):104-106. 被引量：1
-
9褚嘉祐.怎样看待疾病的遗传因素[J].健康世界,2012(10):100-101.
-
10袁艺,白雪.原发性高血压血管紧张素原基因研究[J].河南中医,2014,34(3):422-424. 被引量：8
