摘要
目的:研制己酮可可碱缓释胶囊,确定其体外释放度测定方法。方法:采用挤出滚圆法制取含药小丸,再对小丸进行缓释包衣,制得缓释小丸。采用紫外分光光度法测定其体外释放度,并进行方法验证。结果:自制缓释胶囊粒间、批间差异小;采用紫外分光光度法测定其体外释放度,线性范围4～20μg·ml^(-1),线性方程:A=0.036 1C+0.0009(r=1.0000)。平均回收率为98.8%,RSD=1.4%(n=6)。结论:采用紫外分光光度法测定其体外释放度方便、快速、准确。
Objective： To study release rate of pentoxifylline sustained release capsules in vitro. Method： The core pellets was prepared with extrusion-spheronization, The sustained releace pellet was made after coating the cores. The relense rate in vitro was determined by UV, and evaluated. Result： The linearity was obtained over 4 - 20μg·ml^-1, linear equation was A = 0. 0361 C ＋ 0. 0009 （r = 1. 0000）. The arerage recovery was 98.8% and RSD was 1.4% （n = 6）Conclusion： The method appeared to be rapid, simple, accurate and easy to do.
出处
《中国药师》
CAS
2008年第1期70-72,共3页
China Pharmacist
