摘要
目的:通过对艾滋病患者骨髓象及外周血象异常改变的分析,以便临床正确地采取治疗方案和预防措施。方法:对40例艾滋病患者进行临床、外周血细胞检查、骨髓细胞形态学检查等资料进行分析。结果:40例艾滋病患者均伴有外周血细胞一系、二系或三系的减少,95%的艾滋病患者骨髓细胞增生活跃,5%的艾滋病患者骨髓细胞增生减低。在40例艾滋病患者中,反应性早幼粒细胞增多者占15%,感染性骨髓象和巨幼细胞性贫血各占5%,真菌感染性骨髓象和特发性血小板减少性紫癜各占2.5%,纯红再障和生成减少性粒细胞缺乏痘各占2.5%。结论:外周血细胞和骨髓细胞的异常是艾滋病患者常见的血液学改变,不仅与HIV及其基因产物扰乱辅助细胞的造血调节功能,从而影响造血干细胞的增殖和分化相关,还与AIDS的机会性感染相关。
Objective To study bone marrow and peripheral blood cells abnormalities in 40 patients with AIDS so that patients with AIDS are correctly treated and prevented. Methods To analyse clinical appearance and data of the bone marrow and peripheral blood cells of 40 patients with AIDS. Results 40 patients with AIDS were accompanied by decrease of white blood cell, anemia, thrombocytopenia or two lessening of white blood cell, hemoglobin and platelets or pancytopenia. Bone marrow was hypercellnlar in 95% and hypocellalar in 5% of AIDS. Among the cases, hypergranular promyelocytic was present in 15%. Infected bone marrow and megaloblastic anemia were observed in 5% respectively. Fungi infected bone marrow and idiopathic thrombocytopenic purpura were found in 2.5% respectively. Pure red cell aplasia and granulocytic series deficiency due to regenerative granulocyte failure were observed in 2. 5% respectively. Conclusion It is commonly that Bone marrow and peripheral blood cells became abnormalities in AIDS. The abnormalities associated with HIV-1 and its gene products in the hematopoietic defects perturbing the hematopoietic regulatory function of auxiliary cells which imposed growth and differentiation of hematopoietic progenitor cells. And also the abnormalities were result from the chance infection of AIDS.
出处
《实用医技杂志》
2007年第34期4682-4684,共3页
Journal of Practical Medical Techniques
基金
云南省科技国际合作项目资助(2004GH12)
关键词
艾滋病
外周血细胞
骨髓细胞
AIDS
Peripheral blood cell
Bone marrow cell
