摘要
目的:观察妊娠急性脂肪肝(AFLP)发病有无体液免疫反应参与.方法:采用免疫组化染色方法,观察3例AFLP肝组织中各种免疫球蛋白和补体的沉积.结果:例1,2肝小叶的肝血窦内皮细胞上均有大量IgG、C1q或C4c粗颗粒状沉积,血窦内枯否氏细胞吞噬IgG、IgM、IgA及C1q阳性颗粒,汇管区有不等量C1q沉积和血管内皮细胞C4d.例3肝血窦内皮细胞和汇管区有较多IgG、IgM、IgA沉积,但补体沉积很少.结论:AFLP肝脏组织中存在不同程度的体液免疫反应,可能是其重要的发病因素.
AIM： To observe whether humoral immunity reactions participate in acute fatty liver during pregnancy （AFLP）. METHODS： The deposition of all kinds of immunoglobulin and complements was observed in three cases of AFLP by immunohistochemical staining. RESULTS： In cases 1 and 2, many rough particles of IgG, Clq or C4c were deposited in hepatic sinusoidal endothelial cells, while Kupffer cells swallowed many positive particles of IgG, IgM, IgA and Clq. Different amounts of Clq and C4d were deposited in the portal area and vessel endothelial cells, respectively in case 3, many IgG, IgM and IgA molecules were deposited in hepatic sinusoidal endothelial cells and portal area, but very few complements were deposited. CONCLUSION： The hepatic tissue of AFLP pa- tients has various degrees of humoral immunity reaction, which may be development of AFLP. important factors in the development of AFLP.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第34期3637-3640,共4页
World Chinese Journal of Digestology
关键词
妊娠急性脂肪肝
免疫球蛋白
补体
免疫组化
Acute fatty liver during pregnancy
Im-munoglobulin
Complement
Immunohistochemistry
