摘要
目的：探讨慢性前列腺炎引起膀胱功能异常的神经机制。方法：用荧光素逆行双标法进行研究。将17只成年Wistar雄性大鼠随机分为实验组（12只）和对照组（5只），实验组将荧光素碘化丙啶（Propidium Iodide，PI）注入前列腺右叶，双苯甲亚胺（Bisbenzimide，Bb）注入膀胱右侧壁肌层内。结果：在L。～S3和L，～k的后根神经节（Dorsal root ganglia，DRG）中发现荧光素双标细胞，对照组无双标细胞。结论：腰、骶部的DRG细胞周围突有分支同时投射到前列腺和膀胱，说明慢性前列腺炎引起的排尿异常的发生机制可能与发生在DRG水平的轴突反射有关。
Objective ： To explore the possible neural mechanism underling the abnormal urinary bladder functions induced by chronic prostatitis. Methods ： The retrograde fluorescent double labeling method was applied as the main approach . A total of 17 male Wistar rats were randomly divided two groups, experimental group（12） and control group（5）. In the first group, Propidium Iodide（PI） was injected into the right lobe of the prostate as well as simultaneous Bisbenzimide（Bb） injection into the right wall of the urinary bladder. Results：The fluorescent double labeled neurons were found in the L6-S3 and L1-3 dorsal root ganglia（DRG）. Conclusions：The DRG at L6 -S3 and L1-3 supply both the prostate and the urinary bladder which indicate the micturition abnormity due to chronic prostatitis may be caused by ＂axis reflex＂ at the level of the peripheral process of DRG cells.
出处
《临床泌尿外科杂志》
2007年第12期935-936,939,共3页
Journal of Clinical Urology
关键词
神经机制
膀胱功能异常
前列腺炎
Neural mechanism, Abnormal bladder functions
Prostatitis
