摘要
观察了４０例Ⅱ型糖尿病（ＮＩＤＤＭ）伴发冠心病（ＣＨＤ）患者及３２例ＮＩＤＤＭ无心脑肾并发症患者（对照组）血脂水平及丙二醛（ＭＤＡ）和超氧化物歧化酶（ＳＯＤ）的血清含量，结果显示，除胆固醇外，其余各指标两组间均有显著差异。ＣＨＤ组ＭＤＡ明显高于对照组，而ＳＯＤ则明显低于对照组。多元线性相关分析表明，低密度脂蛋白胆固醇与ＭＤＡ呈显著正相关（ｒ＝０．５７１２；Ｐ＜０．００１）。高密度脂蛋白胆固醇与ＳＯＤ呈显著正相关（（ｒ＝０．５１１２；Ｐ＜０．００１）。提示ＮＩＤＤＭ患者伴发冠心病高脂血症与脂质过氧化间有一定的关系。
The levels of serum lipoprotein(a) Lp(a) ,apolipoprotein A 1(Apo A 1),apolipoprotein B(Apo B),high density lipoprotein cholesterol(HDL c),lower density lipoprotein cholesterol(LDL c),total cholesterol(TC),triglyceride(TG),malondialdehyde(MDA),and superoxide dismutase(SOD) were measured in 40 cases of type Ⅱ diabetes mellitus non insulin dependent diabetes mellitus(NIDDM) accompanied with coronary heart disease(CHD) and 32 NIDDM patients without lheart,brain and kidney complications as control.The results showed that there were significant differences between two groups in all the indices except TC.Lp(a),Apo B,LDL c,and MDA were higher,Apo A 1,HDL c,and SOD were lower in CHD NIDDM group than in the controls( P<0 05 or P <0.01).Multiple correlation analysis revealed that the levels of LDL c correlated significantly with the level of MDA( r=0.5712,P<0.001 ).The level of HDL c correlated significantly with serum SOD activity( r=0 5112,P<0 001). It suggested that hyperlipemia was related to lipids peroxidation in NIDDM patients accompany with CHD.
出处
《中国慢性病预防与控制》
CAS
1997年第4期157-158,177,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
关键词
糖尿病
冠心病
血清脂质
丙二醛
NIDDM\ Coronary heart disease\ Serum lipids\ Malondialdehyde
