摘要
为了解中国人多发性硬化（ＭＳ）患者认知障碍的特点，采用韦氏成人智力量表、临床记忆量表和体感刺激诱发的事件相关脑诱发电位，对两组５５例ＭＳ患者和７１例健康人进行了检测比较。结果显示：ＭＳ患者可出现不同程度的智能、记忆障碍，其智商＜８０分者的记忆商（ＭＱ）、全量表智商（ＦＩＱ）、语言智商（ＶＩＱ）和操作智商（ＰＩＱ）分别为７６．５％、３２．４％、２３．５％、７０．６％（Ｐ＜０．０１）；ＭＳ脑或脑脊髓型智能障碍较脊髓型严重（Ｐ＜０．０１）；活动期智能障碍较非活动期严重（Ｐ＜０．０１）。临床表现脊髓型５７％有记忆障碍，１４％有智能低下，提示脊髓型中部分病人合并脑实质微小病变。ＭＳ缓解复发型、缓解进展型表现为皮质下痴呆的神经心理特征，在慢性进展型表现为皮质兼皮质下混合型痴呆的特征。ＭＳ两组Ｎ２、Ｐ３００波潜伏期延长（Ｐ＜０．００１），波幅明显降低（Ｐ＜０．００１）。提示对ＭＳ患者进行智能、记忆、事件相关电位检测，对掌握ＭＳ病情进展、治疗效果及预后有重要意义。
To learn the characteristics of cognitive disturbance of patients with multiple sclerosis (MS). We divided 55 patients with MS into two groups and 71 normal subjects were tested with the Wechsler Adult Intelligence Scale, Clinical Memory Scale and Eventrelated potentials (ERP). Disturbances of intelligence and memory occurred along the course of MS at various degrees. The memory quotient (MQ), full intelligence quotient (FIQ), verbal quotient (VIQ) and proce ssing quotient (PIQ) of patients with the intelligence quotient (IQ) less than 80 scores were 76%, 32%, 24% and 70% respectively ( P <0.01). The scores of MQ, FIQ and VIQ in patients with MS of cerebral type or cerebro spine type was lower than those of the spine type ( P <0.005). The score of patients with MS in active stage was less than that of MS in inactive stage ( P <0.001). The intelligence disturbances of MS patients were usually characterized by subcortical dementia and showed slight or moderate degree by DSM Ⅲ criteria. In patients of chronic active type, it may be characterized either by cortical dementia or subcortical dementia and showed moderate or severe degree. MS2 patient had significantly prolonged N2 and P300 latencies difference as well as low P300 amplitude compared with controls ( P <0.001). The disterbance of intelligence and memory with MS shows the important implication for the course of MS and the therapeutic effect as well as the prognosis.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第6期372-376,共5页
Chinese Journal of Internal Medicine
基金
河南省科委科研基金
