摘要
目的探讨与重症急性胰腺炎(SAP)早期胰腺感染有关的危险因素。方法回顾性分析2002年1月—2007年3月间收治的86例重症急性胰腺炎患者的年龄、性别、病因、入院时APACHEⅡ评分、血淀粉酶、血钙、血糖、血细胞比容、平均动脉压、ALT、AST、总胆红素、血清白蛋白、血肌酐、尿素氮、胰腺坏死、低氧血症、机械通气、肠功能障碍及导管应用等因素和胰腺感染的相关性。结果禁食时间、胰腺坏死程度、胆源性致病因素、低氧血症、肠功能障碍、血肌酐、尿素氮和入院血细胞比容与 SAP 患者继发感染的发生率呈正相关(P<0.05),血清白蛋白水平与 SAP 患者继发感染的发生率呈负相关(P<0.01);其余各影响因素与胰腺感染均无明显相关性(P>0.05)。结论在SAP 发病过程中,禁食时间较长、胰腺坏死程度增高、胆源性致病因素、低氧血症、肠功能障碍以及血肌酐、尿素氮和入院血细胞比容的升高可能是导致胰腺发生感染的重要因素。
Objective To investigate predisposing factors for early infection in patients with severe acute pancreatitis. Methods The clinical and laboratory data including age,gender,APACHEⅡ score on admission,hemodiastase,mechanical ventilation,blood calcium,mean arterial blood pressure,blood glucose, alanine aminotransferase, aspartate aminotransferase, total bilirubin, necrosis of the pancreas, hypoxemia, entero-functional disturbance, etiological factor, serum albumin, serum creatinine, urea nitrogen and haematocrit were analyzed by multiple linear regression in relation with the infection incidence in the 86 SAP patients hospitalized from Jan 2002 to Mar 2007. Results The fasting time, biliary pancreatitis, hypoxemia, necrosis of pancreas, entero-functional disturbance, serum creatinine, urea nitrogen and haematocrit were positively correlated with the incidence of pancreatic infection （ all P 〈 0. 05 ） and serum albumin was negatively correlated with the incidence of pancreatic infection （P 〈 0.01 ）. Conclusions Fasting time, biliary pancreatitis, hypoxemia, necrosis of pancreas, entero-functional disturbance,operation,serum creatinine,urea nitrogen and haematocrit may be the important factors in the pancreatic infection.
出处
《中华普通外科杂志》
CSCD
北大核心
2007年第12期892-895,共4页
Chinese Journal of General Surgery
关键词
胰腺炎
急性坏死性
感染
危险因素
Pancreatitis, acute necrotizing
Infection
Risk factors
