摘要
背景与目的:恶性胶质瘤单纯手术与常规放疗疗效不佳,我们应用静态多叶准直器逆向调强方法在2年中治疗28例恶性胶质瘤,观察其近期疗效与副反应。方法:采用准直器静态逆向调强方式,分割剂量2～8Gy/次,每周3￣5次,治疗次数8～35次,绝对剂量45～70Gy,调整生物剂量55～78Gy,相关正常组织的受照剂量限定在耐受剂量之下。随访观察12～24个月。结果:1年生存率为24/26(92.3%);CR+PR16/26(61.5%);NC5/26(19.2%);PD3/26(11.5%),死亡2/26(7.7%)。轻度头晕、呕吐发生率19/26(73%);嗜睡与低热为5/26(19%),未见严重的早期放射反应与晚期放射反应。结论:静态多叶光栅逆向调强放疗可使恶性胶质瘤靶区剂量提高到55～78Gy,未见严重的急性早期放射反应和晚期放射反应,操作方便可行,一年生存率高。
BACKGROUND ＆ OBJECTIVE： Regardless of surgery and regular radiotherapy, the overall prognosis of malignant gliomas remains poor. In this paper, we investigated short-term effect and treatment-related toxicity of intensity-modulated radiotherapy （IMRT） in the treatment of 28 patients with malignant gliomas. METHODS： Twenty-eight patients with malignant gliomas were treated with ＂Stop and Shoot＂ static IMRT. A dose of 45-70 Gy at 2-8 Gy per fraction is delivered. The biological effective dose was 55-78 Gy. Patients were followed up for 12-24 months. RESULTS： Among 26 patients, the 1-year-survival rate was 92.3%. The overall response rate（CR＋PR） was 61.5% （16/26）.NC and PD were 19.2%（5/26）,and 11.5%（3/26）.respectively. Two patients（7.7%） died.dead 2（7.7%）. Radiotherapery-related toxicity included mild dizzy or vomiting 19/26（73%） andlethargy or low-grade fever 5/26（19%）. No severe acute and late radiation reactions were observed. CONCLUSION： The target dose in glioma can be raised to 55-78Gy with ＂Stop and Shoot＂. No severe acute and late stage radiation reactions are observed in this goup of patients.Patients treated with ＂Stop and Shoot＂ IMRT have a high rate of 1-year survival.
出处
《中国神经肿瘤杂志》
2007年第4期262-264,共3页
Chinese Journal of Neuro-Oncology
基金
广东省医学科学研究基金(A2005538)
