摘要
细胞色素P450(cytochrome P450,CYP450)酶系,是人体中与药物代谢密切相关的重要酶系之一,90%以上的药物的氧化是由P450酶催化的。多药合用对机体P450酶的影响,能造成临床上显著的药物相互作用。基于P450独特的功能和特点,可以预测、控制药物的相互作用,并可能解释某患者对特定治疗方案的反应。该文从细胞色素P450分类及其各自的催化特点,心血管药物相互作用与细胞色素P450酶的关系方面进行探讨,为指导临床安全、合理的用药,增加患者依从性提供参考。
Cytochrome P450 （CYP450） is one of the most important enzyme systems that involves in the metabolism of drugs in vivo. There are about 90% of drugs are oxidized by CYP450, The effects of multidrug on CYP450 may induce notable clinical drug - drug interactions （DDI）. Based on the unique function and character of Cytochrome P450, drug- drug interaction could be predicted and controlled. Furthermore, a patient＇s response to specified therapeutic regimen could also be explained. In this article, researches on the classification and respectively catalytic characteristic of CYP450 and drug- drug interaction among cardiovascular drugs induced by CYP450 were investigated for safety and rationality of clinical medication and for the advancement of patients＇ compliance.
出处
《医学与哲学（B）》
2007年第12期55-57,共3页
Medicine & Philosophy(B)
