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重症肌无力患者外周血CD_4^+CD_(25)^+调节性T细胞的表达 被引量：1

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摘要 目的:观察免疫治疗对重症肌无力(MG)患者外周血CD4+CD2+5T淋巴细胞表达的影响。方法:应用四色流式细胞术对MG30例(观察组)治疗前后和30例健康者(对照组)外周血CD4+CD2+5、CD4+、CD2+5T淋巴细胞亚群等表达进行检测,以CD25抗原荧光强度10的细胞定义为CD2hi5gh细胞,分析其百分率和荧光强度,并结合临床资料进行相关分析。结果:观察组治疗前外周血CD4+CD2+5、CD4+CDh2i5gh、CD2+5占总淋巴细胞的比例与正常对照组无显著差异(P>0.05),但CD4+细胞数较正常增高(P<0.05);经类固醇激素或经胸腺切除治疗后,外周血CD4+CD2+5、CD4+CDh2i5gh与治疗前及对照组比较,差异显著(P<0.05)。结论:经免疫治疗后的MG患者外周血中存在高比例的CD4+CD2+5表达,可能与病情缓解有关。
作者 孙旭 牛广华
机构地区 武警辽宁省总队医院 辽宁省中医医院临床检验中心
出处 《人民军医》 2008年第2期91-92,共2页 People's Military Surgeon
关键词 重症肌无力 调节性T细胞 免疫疗法
分类号 R746.1 [医药卫生—神经病学与精神病学]
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参考文献4

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同被引文献25

  • 1Mqadmi A, Zheng XY, Yazdanbakhsh K. CD4^+ CD25^ regulatory T - cells control induction of autoimmune hemolytic anemia. Blood, 2005,105:3746 - 3748.
  • 2Ward FJ, Hall AM, Cairns LS, et al. Clonal regulatory T - cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemi - a. Blood, 2008,111:680 - 687.
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  • 7Foussat A, Cott fez F, Bran V, et al. A comparative study between T - regulatory typel and CD4^+ CD25^ T cells in the control of inflammation. J Immunol 2003,171:5018 - 5026.
  • 8Brimnes J, Allez M, Dotan I, et al. Defects in CD8^+ regulatory T -cells inthe lamina propria of patients with inflammatory bowel disease. J Immunol,2005,174:5814 - 5822.
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  • 10Sakaguchi S. Naturally arising Foxp3 - experessing CD4+ CD25+ regulatory T - cells in immunological tolerance to self. Nat Immuno1,2005, 699(4) :345-352.

引证文献1

人民军医
2008年 第2期

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