摘要
利用光学方法无创伤地检测人体血糖浓度是目前的一个研究热点.分析了经皮漫反射光谱测量人体血糖的原理,针对信号微弱、生理背景噪声难以直接定量等现状,利用Monte Carlo模拟方法初步计算了血糖浓度和人体温度变化导致的漫反射光强,并通过葡萄糖水溶液实验对模拟计算的有效性进行了验证,最后根据两名糖尿病患者的口服葡萄糖耐量实验,估计了活体实验中的温度变化对血糖浓度模型误差的影响.结果表明,在37℃附近,体温降低0.1℃引起的漫反射光强与血糖浓度升高2.7 mmol/L相当,而对基于近红外光谱的无创血糖预测,体温是一个非常重要的误差源,它对模型的影响占总误差的50%以上.
Aiming at noninvasive blood glucose sensing by near-infrared spectroscopy, the principle of transcutaneous glucose measurement was analyzed. Due to the weak signal and the difficulty in quantifying the physiological noise directly, Monte Carlo simulation was used to compute the light intensity induced by the change in glucose concentration and physiological temperature. And the reliability of simulation computation was validated using glucose aqueous solution. Finally, the influence of actual physiological temperature on the prediction model of glucose concentration was estimated based on the oral glucose tolerance tests of two diabetics. The result showed that, near the normal temperature of 37 ℃, the intensity of diffuse reflectance caused by - 0.1 ℃ change in temperature was equivalent to that caused by ＋ 2.7 mmol/L change in glucose concentration. Moreover, temperature was one of the most significant error sources for the blood glucose prediction by near-infrared spectroscopy, and the ratio of the error induced by temperature to the total error was more than 50 %.
出处
《天津大学学报》
EI
CAS
CSCD
北大核心
2008年第1期1-6,共6页
Journal of Tianjin University(Science and Technology)
基金
"十一五"国家科技支撑计划资助项目(2006BAI03A03)
中国博士后科学基金资助项目(20070410197)
关键词
血糖
近红外光谱
体温
无创测量
blood glucose
near-infrared spectroscopy
temperature
noninvasive measurement
