摘要
目的:评价肺靶向红霉素明胶微球(EM-GMS)的安全性。方法:对EM-GMS、注射用乳糖酸红霉素(EM)、空白明胶微球(GMS)进行小鼠急性毒性半数致死量(LD50)实验;以生理盐水为对照进行EM-GMS兔耳缘静脉血管刺激性、豚鼠全身过敏性及体外溶血实验。结果:小鼠尾静脉注射EM-GMS、GMS、EM后LD50分别为173.07、191.01、337.70mg.kg-1;与生理盐水比较,未观察到EM-GMS发生血管刺激性、过敏反应及溶血作用。结论:EM-GMS应用于受试动物安全性较好。
OBJECTIVE： To evaluate the safety of the lung targeting erythromycin gelatin microspheres （EM-GMS） . METHODS： The acute toxicity LD50 test was conducted in mice with EM- GMS, erythromycin（EM） and GMS, respectively; the stimulating test in rabbits＇ auricular veins, allergic test and hemolysis test in vitro in guinea pigs were conducted with normal saline used as control. RESULTS： The LD50 in mice after iv of EM-GMS, GMS, and EM were 173.07, 191.01, and 337.70 mg . kg^-1. As compared with control, neither vascular stimulation, nor allergic response or hemolysis was noted after intervention with EM- GMS. CONCLUSION： The EM- GSM has good safety on test animals.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第4期261-263,共3页
China Pharmacy
基金
广东省科技计划资助项目(2005B30101015)
广州市科技计划资助项目(2005Z3E0541)
关键词
红霉素明胶微球
急性毒性
溶血实验
血管刺激性
过敏性反应
Erythromycin gelatin microspheres
Acute toxicity
Hemolytic test
Vascular stimulation
Allergic reaction
