摘要
目的对比卡维地洛与美托洛尔两种不同类型的β-受体阻滞剂对高血压心脏病患者心室重塑的影响。方法将92例高血压心脏病患者随机分成2组,在常规治疗的基础上,分别口服卡维地洛(A组,46例)和美托洛尔(B组,46例)。应用超声心动图分别在治疗前、治疗6个月及12个月测量室间隔厚度(IVS),左室后壁厚度(IVPW),左室重量指数(LVMI),左室球径指数(LVGI)。结果治疗6个月时,两组LV-MI,LVGI较治疗前明显减少,A组较B组减少更显著;治疗12个月时,两组IVS,IVPW,LVMI,LVGI均较治疗前显著改善,A组与B组比较,IVPW,LVMI,LVGI差异有显著性。结论卡维地洛在改善心室重塑方面较美托洛尔更显著。
Objective To compare the different influences of β-blockers carvidilol and metrolol on ventricular remodeling in hypertensive heart disease. Methods 92 cases of hypertensive heart disease were divided into two groups randomly. Besides the normal medicine, group A was given carvidilol （46 cases）, while group B was given metrolol （46 cases）. Ventricular remodeling was calculated by measuring interventricular septum （IVS）,left ventricular post wall （LVPW）,left ventricular mass index （LVMI） and left ventricular global-diameter index （LVGI） with ultrasonic cardiograph in the beginning and after 6, 12 months of the treatment. Results After 6 months of treatment, LVMI, LVGI descreased significantly, especially in group A; after 12 months with more significant improvement in group A. Conclusion Carvidilol the treatment of hypertensive heart disease. of treatment, IVS, LVPW, LVMI, LVGI were all improved significantly, shows superiority than metrolol in improving ventricular remodeling in
出处
《中国药业》
CAS
2008年第3期46-47,共2页
China Pharmaceuticals
关键词
高血压心脏病
卡维地洛
美托洛尔
心室重塑
hypertensive heart disease
carvidilol
metrolol
ventricular remodeling
