摘要
应用酶标双抗夹心法（ELISA）检测30例糖尿病患者血清肿瘤坏死因子（TNF-α）的变化。结果发现，未经治疗糖尿病患者血清TNF-α水平明显高于正常对照组（P＜0．001）。对20例糖尿病患者治疗前后血清TNF-α进行动态观察，糖尿病患者治疗前血清TNF-α明显高于治疗后（P＜0．01）。伴有血管并发症糖尿病患者血清TNF-α较无血管井发症糖尿病患者显著升高（P＜0．001）。糖尿病患者血清TNF-α水平与空腹血糖（FBG）、糖化血红蛋白（HbA1C）均呈显著性正相关。结果表明，糖尿病患者血清TNF-α水平增高，TNF-α与高血糖状态及糖尿病血管并发症的发生发展有一定的关系。
By the method of ELISA, authors surveyed the changes of serum tumor necrosis factor-alpha(TNFa) in 30 diabetics. The results showed that the level of TNF-a in patients of the untreated group was significantlyhigher than those of normal control group (P<0. 001 ). Changes of TNF-a were monitored in 20 diabetics beforeand after treatment. A higher TNF-a level was found in the pretreatment group than that in the posttreatmentgroup (P<0. 01 ). TNF-a was in much higher level in the diabetics with vascular complications than those without(P<0. 001 ). There was a positive correlation between the TNF-a level and FBG、HbA1C in the diabetic patients.We concluded that the diabetics with higher level of TNF-a in serum is correlated with the occurrence anddevelopment of diabetic complications and hyperglycemia.
出处
《江苏医药》
CAS
CSCD
1997年第9期614-616,共3页
Jiangsu Medical Journal
关键词
糖尿病
肿瘤坏死因子
细胞因子
Diabetes mellitus Tumor necrosis factor Cytokines
