摘要
目的:研究当归超微粉直接压片成型的工艺。方法:采用混料均匀设计法,以片重差异、脆碎度为限制条件,以硬度、崩解度的综合评分为指标建立回归方程,求出综合最优解,对当归超微粉片处方进行优化。用DPS软件进行数据运算。结果:最佳处方为应用粉末直接压片法制备片剂,其硬度可达到75N,崩解时间为10.24min,且片面光滑无缺。结论:该工艺处方合理、成型性好,可为工业化生产提供理论依据。
OBJECTIVE： To study the direct powder compression technology of Angelica micropowder. METHODS： The formula of Angelica micropowder was optimized by mixture uniform design with tablet weight variation and friability as re strictive conditions, and a regression equation was established based on the comprehensive grading on the hardness and disintegration to figure out the optimal solution. DPS software was applied in the calculation, RESULTS： Prepared by the direct powder compression technology, the optimal formula of Angelica micropowder was obtained as follows： the hardness of the optimized tablet could reach as high as 75 N and the disintegrating time was about 10.24 min, with smooth and intact surface. CONCLUSION： The technology is reasonable in formulation and satisfactory in molding, and it can serve as theoretical basis for the production of Angelica tablets.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第3期183-185,共3页
China Pharmacy
