摘要
比较了IL－2及IL－7诱导的40例健康育中年人。46例健康老年人及21例老年肿瘤患者外周血LAK细胞活性。结果表明，健康老年组IL－2诱导的LAK细胞活性明显高于老年肿瘤患者（P＜0.01），但明显低于健康青中年组（P＜0．01）；健康老年组及健康青中年组IL－7诱导的LAK细胞活性均明显高于老年肿瘤患者，但二者之间无显著差异；抗IL－2抗体能够抑制IL－2诱导的LAK细胞活性，但对IL－7诱导的LAK活性不影响；老年肿瘤患者血浆能够明显抑制IL－2及IL－7诱导的正常人外周血LAK细胞活性。
IL-2 and IL-7-induced LAK activities in the peripheral blood mononuclear cells of 40 healthy adults, 46 healthy aged individuals and 21 aged patients with cancer were investigated. The data demonstrated that IL-2-induced LAK activity in the healthy aged individuals were markedly higher than the aged cancer patients,but significantly lower than the healthy individuals. However, no difference was found between the healthy aged and healthy adults on IL-7-induced LAK activities. An anti-IL-2 antibody can inhibit IL-2-inducedLAK activity in normal human peripheral blood mononuclear cells but not IL-7-induced LAK activity. The plasma from aged patients with cancer had an obvious inhibition to both the IL-2 and IL-7-induced LAK ac-tlvities.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1997年第4期214-215,共2页
Chinese Journal of Gerontology
