摘要
简要介绍了中子俘获治疗（ＮＣＴ）的原理、发展历史及最新进展，指出成功地实现ＮＣＴ需要高质量的超热中子束、高选择性的ＮＣＴ药物、严格的剂量计算和测量及周密的治疗方案。本文对加速器和反应堆产生超热中子束的两种方法及质量要求作了较详细的讨论，对ＢＮＣＴ、ＧｄＮＣＴ、ＬｉＮＣＴ、ＵＮＣＴ及相关的药物进行了比较性评述，并对我国开展ＮＣＴ研究提出了建议。
The principle of neutron capture therapy (NCT), its historical evolution, and the latest developments were briefly described. The successful application of NCT needs high quality epithermal neutron beams, highly selective NCT drugs, accurate dose calculation and measurements, and well conceived therapeutic planning. Two possible kinds of facilities for production of epithermal neutron beam, i.e., nuclear reactors and particle accelerators were discussed. The requirements for epithermal neutron beam were also included. The comparative evaluation of four possible NCT varieties, BNCT, GdNCT, LiNCT, UNCT, and relevant tumor seeking drugs were given. The conduction of NCT research in China was finally suggested.
出处
《化学进展》
SCIE
CAS
CSCD
1997年第1期99-105,共7页
Progress in Chemistry
基金
国家科委"九五"攀登计划资助
关键词
中子俘获治疗法
癌症
超热中子束
neutron capture therapy(NCT)
BNCT
GdNCT
LiNCT
UNCT
NCT drugs
epithermal neutron beam
