摘要
目的:探讨慢性肺源性心脏病(CPHD)急性加重期糖代谢的临床特点。方法:将18例无糖尿病史CPHD急性加重期并经约2周治疗后缓解的患者,分别于治疗初和治疗缓解后进行口服葡萄糖耐量实验、胰岛素释放实验和血清C肽测定,同时对正常对照组进行口服葡萄糖耐量实验。结果:1CPHD急性加重期治疗初空腹血糖为6.37±1.26mmol/L,显著高于治疗缓解期(5.23±1.18mmol/L)和对照组(4.68±1.04mmol/L),P均<0.05,其后各时间点血糖值,急性加重期治疗初均高于治疗缓解期和对照组(P均<0.05),CPHD治疗缓解期各时间点血糖均值皆高于对照组,但无显著性差异(P均<0.05);2CPHD急性加重期治疗初空腹胰岛素为7.65±2.16mU/L,血清C肽为0.81±0.16mg/ml,显著低于治疗缓解后的10.84±3.27mU/L和1.13±0.28mg/ml(P均>0.05),其后各时间点胰岛素和C肽值,急性加重期治疗初均低于治疗缓解期(P均<0.05);急性加重期治疗初胰岛素释放曲线和C肽较缓解期低平。结论:CPHD急性加重期患者糖代谢存在异常,空腹血糖和餐后血糖均高于正常对照组,其原因可能与胰岛素释放减少有关。
Objective ：To investigate clinical characters of acute exacerbation of chronic pulmonary heart disease （CPHD）. Methods ： 18 patients of acute exacerbation of CPHD, who had no history of diabetic mellitus and recovered by the treatment of two weeks,underwent oral glucose tolerance test （OGTT）, insulin release test （IRT）, and measured the content of serum C-peptide was measured before and after treatment. Meanwhile the normal control cases underwent OGTT. Results ：（1） Fasting plasma glucose （FPG）and postprandial blood sugar （PPBS）of acute exacerbation of CPHD were significantly higher than those of the recovery stage of CPHD and the control group（P〈0.05）; The mean FPG and PPBS of the recovery stage of CPHD were higher than those of the control group, but there was not significant difference （P〉0.05）. （2） The contents of serum insulin and C-peptide of acute exacerbation of CPHD in different time were significantly lower than those of the recovery stage of CPHD（P〈0.05） ; The curve of insulin-releasing and C-peptide were low and flat. Conclusion ： Glucose metabolism of patients with acute exacerbation of CPHD is abnormal. FPG and PPBS in these patients are higher than the normal control group ,the reason of which may be the decreasing of insulinreleasing.
出处
《陕西医学杂志》
CAS
北大核心
2008年第1期69-71,共3页
Shaanxi Medical Journal
关键词
肺心病/血液
血糖/代谢
胰岛素/代谢
Pulmonary heart disease/blood Blood glucose/metabolism Insulin/metabolism
