摘要
目的探讨18F-NaF在骨质疏松症实验研究中的应用价值。方法用过量地塞米松磷酸钠注射法制作大鼠骨质疏松模型,对动物模型注射18F-NaF,进行生物分布研究,测定大鼠各器官对18F-NaF的摄取值。对8例健康志愿者进行胸部动态及全身PET显像,测定骨骼对18F-NaF的摄取。结果骨质疏松大鼠骨骼对18F-NaF的摄取值低于对照组,其中实验组股骨颈、腰椎、第七肋骨及胫骨对18F-NaF的摄取明显低于对照组(P<0.05);健康志愿者胸部动态PET显像发现,在注射后20s,脊柱骨、肱骨、肋骨有明显的18F-NaF摄取,随着时间的延长,骨骼对18F-NaF的摄取逐渐增加,60min摄取达峰值。60min行全身PET显像发现,全身骨骼明显摄取18F-NaF,骨骼/肌肉比值高,平均为8.12。结论18F-NaF是理想的骨血流和代谢显像剂,18F-NaF在正常骨和实验性骨质疏松症骨骼中的分布有明显差异,提示18F-NaF在骨质疏松症的研究中具有潜在应用价值。
Objective To investigate the biodistribution of ^18F-NaF as an imaging agent for position emission tomography （PET） in rat models of osteoporosis. Methods Osteoporosis was induced in lO rats via injection with an excess of dexamethasone phosphate sodium, and the bioistribution of ^18F-NaF in the rats was studied, with another 10 normal rats as the control group. ^18F-NaF PET was also performed in 8 healthy volunteers, and the uptakes of ^18F-F- in the bone tissues were measured. Results Compared with the control rats, the osteoporotic rats showed significantly decreased ^18F-F- uptake, especially in the femoral neck, lumbar vertebrae, the 7th rib and the tibia （P〈0.05）. Dynamic chest PET scanning in the volunteers revealed obvious ^18F-F- uptake in the spine, ribs and humerus 20 s after injection of the imaging agent. ^18F-F- uptake significantly increased with time in the bones, reaching the peak level 60 min after the injection, and whole-body PET at this point demonstrated obvious skeletal ^18F-F- uptake, with high skeletal-to-muscle （STM） ratio that averaged 8.12. Conclusions ^18F-NaF is an excellent skeletal imaging agent for clinical skeletal blood flow and metabolism measurements. The uptake of ^18F-NaF has significant difference between normal and osteoporotic bone tissues, indicating the value of ^18F-NaF PET for study of osteoporosis.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第1期76-78,共3页
Journal of Southern Medical University
基金
广东科技计划项目(2003C34301)~~
